Skip to main content

Advertisement

Table 4 Attenuation of strength of the association of very low HbA1c levels (<5 % (<31 mmol/mol)) with all-cause and cardiovascular mortality by adding potential confounders to the “simple” model in the NHANES

From: HbA1c levels in non-diabetic older adults – No J-shaped associations with primary cardiovascular events, cardiovascular and all-cause mortality after adjustment for confounders in a meta-analysis of individual participant data from six cohort studies

Model HR (95 % CI)a Attenuation for both outcomes
All-cause mortality CV mortality
Age + sex (“simple” model) 1.201 (1.057; 1.328) 1.221 (1.005; 1.409) N/A
Age + sex + race/ethnicity 1.184 (1.042; 1.341) 1.203 (0.989; 1.453) Yes
Age + sex + alcohol consumption 1.192 (1.051; 1.353) 1.212 (1.000; 1.469) Yes
Age + sex + BMI 1.172 (1.033; 1.330) 1.197 (0.988; 1.450) Yes
Age + sex + physical activity 1.208 (1.065; 1.370) 1.231 (1.016; 1.491) No
Age + sex + hemoglobin 1.166 (1.027; 1.324) 1.188 (0.980; 1.440) Yes
Age + sex + ferritin 1.193 (1.052; 1.354) 1.211 (0.999; 1.467) Yes
Age + sex + total cholesterol 1.192 (1.051; 1.353) 1.226 (1.012; 1.486) No
Age + sex + erythrocyte protoporphyrin 1.177 (1.036; 1.337) 1.208 (0.995; 1.466) Yes
Age + sex + GGT 1.178 (1.038; 1.337) 1.206 (0.995; 1.462) Yes
Age + sex + AST 1.199 (1.057; 1.361) 1.222 (1.009; 1.481) No
Age + sex + ALT 1.199 (1.057; 1.360) 1.215 (1.003; 1.472) Yes
Age + sex + race/ethnicity + alcohol consumption + BMI + ferritin + erythrocyte protoporphyrin + GGT + ALT 1.081 (0.950; 1.230) 1.106 (0.909; 1.345)  
All variables of Table 1 1.103 (0.968; 1.256) 1.120 (0.921; 1.363)  
  1. aReference group: low HbA1c (5.0 to <5.5 % (31 to <37 mmol/mol)). ALT, alanine transferase; AST, aspartate transferase; BMI, body mass index; CV, cardiovascular; GGT, gamma-glutamyl transferase; HR, hazard ratio, N/A, not applicable