Fig. 2
From: Fast and accurate dynamic estimation of field effectiveness of meningococcal vaccines
Maximum likelihood profiles for direct and indirect effectiveness against MenC. a The likelihood function of VEdir (y-axis) and VEind (x-axis) calculated using IMD cases reported during the first two full epidemiological years of the MenC immunization campaign in England (cases notified from June 2000 to June 2002). The maximum is colored in light yellow, and unlikely values of VE are in dark blue. The 95 % CI is included inside the white dotted line. The log-likelihood function is sliced around its maximum, as a function of VEdir (b) and VEind (c). The solid line interpolates the discrete values of the log-likelihood to identify the 95 % CLs, as indicated by the vertical dotted lines. CI confidence interval, CL confidence limit, IMD invasive meningococcal disease, loglik log-likelihood, MenC serogroup C meningococcal