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Table 3 Available clinical studies on the effect of peptides on bone healing

From: The role of peptides in bone healing and regeneration: a systematic review

Study, Year Peptide used Clinical application Result
Yukna et al., 1998 [115] P-15 Periodontal osseous defects in 33 patients • P-15 combined with anorganic bone matrix (ABM) yields better clinical results than freeze-dried bone allograft or open flap debridement
Yukna et al., 2000 [114] P-15 Periodontal osseous defects in 33 patients • P-15 combined with ABM yields better clinical results than the ABM alone
Yukna et al., 2002 [122] P-15 Infra-bony periodontal defects in 25 patients • Favourable 3-year results with P-15 combined with ABM suggest that it may have a beneficial effect long-term
Yukna et al., 2002 [109] P-15 Periodontal regeneration case report • Uneventful results with no evidence of root resorption, ankylosis or untoward inflammation
Degidi et al., 2004 [128] P-15 Maxillary sinus augmentation in 7 patients • Bone-replacement materials, without the addition of autologous bone, could be equally effective sinus augmentation
Gelbart et al., 2005 [110] P-15 Sinus floor augmentation in 12 patients • New trabecular bone is formed after grafting P-15 combined with ABM in the sinus floor
Philippart et al., 2005 [130] P-15 Maxillary sinus floor grafting performed on 3 patients • High degree of inorganic xenograft integration and natural bone regeneration
Gomar et al. 2007 [236] P-15 Non-unions and delayed union in 22 patients • Full consolidation was achieved in 90 % of the cases • Safe, economical and clinically useful alternative to autograft in the repair of un-united fractures
Kasaj et al., 2008 [127] P-15 Infra-bony periodontal defects in 26 patients • Significantly improved clinical outcomes compared to open flap debridement
Butz et al., 2011 [116] P-15 Sinus floor augmentation in 24 patients • All implants placed in the augmented sites integrated and were restored prosthetically
Emam et al., 2011 [117] P-15 Sinus floor augmentation in 24 patients • PepGen P-15 putty was found to be a promising osteoconductive graft for sinus augmentation, supporting immediate placement of implants
Aspenberg et al., 2010 [33] Teriparatide Distal radial fractures in 27 patients • The results must be interpreted with caution • Radiographic quality at an early time point might be a sensitive variable, perhaps better than time to cortical continuity • Teriparatide appeared to improve early callus formation in distal radial fractures
Aspenberg et al., 2010 [28] Teriparatide Distal radial fractures in 102 patients • Shortened time to healing for teriparatide group compared with placebo • These results should be interpreted with caution and warrant further study
Chintamaneni et al., 2010 [34] Teriparatide Sternal fracture non-union • Consolidation of fracture
Oteo-Alvaro et al., 2010 [36] Teriparatide Humeral shaft non-union case report • Consolidation of fracture
Chrysalin trial [106] Chrysalin Distal radial fractures in 274 patients • Statistically significant shorter time to the radiologic consolidation of the fractures but no differences in terms of the range of motion, grip strength and VAS or DASH scores