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Table 1 List of Mycobacterium tuberculosis clinical strains from the selected cluster RFL15

From: Genetic variation in Mycobacterium tuberculosis isolates from a London outbreak associated with isoniazid resistance

Type Isolate Lineage (clade) Resistant to Sensitive to Polymorphism for INH Relative fitness to H37Rv
Cluster RFL15 02.113 Euro American (Cameroon) - H,R,Z,E,S None detected 0.96
02.292 Euro American (Cameroon) H R,Z,E,S inhA C → T 0.88
02:302a Euro American S H,R,Z,E None detected 1.05
03.013 Euro American (Cameroon) S H,R,Z,E None detected 0.89
03.039 Euro American (Cameroon) H R,Z,E,S inhA C → T 0.82
03.303a Euro American H R,Z,E,S inhA C → T 0.92
03.313 Euro American (Cameroon) S H,R,Z,E None detected 0.98
04.018 Euro American (Cameroon) H, R, clari, ethi Z,E,S inhA C → T 0.75
04.194 Euro American (Uganda) H R,Z,E,S katG S315T 0.96
04:198a Euro American H R,Z,E,S inhA C → T 0.98
04.211 Euro American (Cameroon) H R,Z,E,S inhA C → T 0.93
04.493 Euro American (Cameroon) H R,Z,E,S inhA C → T 1.01
04.503 Euro American (Cameroon) H R,Z,E,S inhA C → T 0.94
05.046 Euro American (Cameroon) - H,R,Z,E,S None detected 1.03
07.116 Euro American (Cameroon) H, ethi R,Z,E,S inhA C → T 0.99
07:118 Euro American (Cameroon) H R,Z,E,S katG S315T 0.82
H-resistant control 05.177 (Control strain 1) Euro American (Uganda) H R,Z,E,S inhA C → T 0.92
H-sensitive control 05.094 (Control strain 2) Euro American (Uganda) - H,R,Z,E,S None detected 0.88
H-sensitive control 04.011 (Control strain 3) East African Indian (Delhi/CAS) - H,R,Z,E,S katG R463L (but no resistance) 0.81
  Mutation rate - outbreak strains Mutation rate - control strains
1.3 × 10−8 × cell division 1.3 × 10−8 × cell division
  1. ano whole-genome sequence available as unable to extract enough DNA
  2. The first two digits in the isolate number indicate the year of isolation, for example, 02:113 was isolated in 2002. Sensitivities were based on phenotypical testing (abbreviations: Clari clarithromycin, Ethi ethionamide, H isoniazid, R rifampicin, Z pyrazinamide, E ethambutol, S streptomycin). Only the genetic mutations conferring isoniazid resistance are reported for simplicity. Strains in bold are closely related on further phylogenetic analysis (see phylogenetic tree)