Table 3 Diagnostic accuracy when basing endoscopy referral on varying SCD probability thresholds for the basic and the five faecal biomarker extended models, as observed in 810 Dutch patients with lower abdominal complaints referred for endoscopy in the CEDAR study^a

 ≥2.5 %

98.0 (96.4–99.2)

141

0

–

–

–

–

99.7 (96.7–100.0)

17.7 (15.2–20.5)

2.3 (1.0–4.1)

98.0 (76.5–100.0)

 ≥5.0 %

86.9 (83.9–89.6)

136

5

–

–

2

3

97.0 (92.6–98.8)

19.4 (16.6–22.5)

15.2 (12.1–18.8)

95.9 (90.2–98.5)

 ≥7.5 %

72.5 (69.1–75.6)

126

15

1

–

4

10

89.5 (83.2–93.8)

21.5 (18.3–25.0)

31.1 (27.5–35.0)

93.4 (89.2–96.1)

 ≥2.5 %

97.9 (96.4–98.9)

141

0

–

–

–

–

100.0 (97.3–100.0)

17.8 (15.3–20.6)

2.6 (1.4–4.3)

100.0 (81.1–100.0)

 ≥5.0 %

83.6 (80.3–86.6)

138

3

–

–

1

2

97.4 (93.1–99.2)

20.3 (17.4–23.5)

19.3 (15.8–23.3)

97.2 (92.6–99.2)

 ≥7.5 %

68.5 (64.9–71.9)

125

16

1

1

5

9

88.1 (81.5–92.7)

22.4 (19.1–26.1)

35.6 (31.7–39.7)

93.4 (89.6–96.0)

 ≥2.5 %

97.6 (96.0–98.8)

141

0

–

–

–

–

100.0 (97.3–100.0)

17.8 (15.3–20.7)

2.9 (1.5–4.8)

100.0 (82.7–100.0)

 ≥5.0 %

84.0 (81.1–86.6)

135

6

–

1

2

3

96.3 (91.5–98.7)

20.0 (17.1–23.2)

18.6 (15.5–22.0)

96.0 (90.7–98.6)

 ≥7.5 %

68.1 (64.7–71.4)

126

15

–

1

5

9

90.0 (83.7–94.2)

23.0 (19.7–26.7)

36.5 (32.8–40.4)

94.5 (91.0–96.8)

 ≥2.5 %

92.8 (89.0–96.2)

140

1

–

–

–

1

99.4 (96.2–100.0)

18.6 (16.0–21.6)

8.6 (4.5–13.1)

98.7 (91.2–99.9)

 ≥5.0 %

69.9 (64.4–75.3)

131

10

1

–

4

5

93.0 (87.4–96.4)

23.2 (19.6–27.1)

34.9 (28.7–41.4)

96.0 (92.6–97.9)

 ≥7.5 %

54.3 (49.6–59.1)

124

17

1

4

6

6

88.1 (81.4–92.8)

28.2 (24.0–32.9)

52.8 (47.4–58.1)

95.5 (92.7–97.2)

 ≥2.5 %

92.8 (89.4–95.7)

141

0

–

–

–

–

100.0 (97.3–100.0)

18.8 (16.1–21.8)

8.7 (5.2–12.8)

100.0 (93.4–100.0)

 ≥5.0 %

69.6 (64.7–74.3)

132

9

1

–

4

4

93.7 (88.2–96.8)

23.5 (19.9–27.3)

35.5 (29.9–41.2)

96.4 (93.1–98.2)

 ≥7.5 %

53.3 (48.7–57.8)

124

17

1

3

7

6

88.4 (81.7–93.1)

28.9 (24.7–33.5)

54.1 (49.1–59.1)

95.7 (93.1–97.4)

 ≥2.5 %

92.8 (89.5–95.6)

141

0

–

–

–

–

100.0 (97.3–100.0)

18.8 (16.1–21.8)

8.7 (5.3–12.7)

100.0 (93.5–100.0)

 ≥5.0 %

69.0 (64.8–73.0)

132

9

1

–

4

4

93.3 (87.7–96.7)

23.6 (20.2–27.3)

36.2 (31.6–40.9)

96.3 (93.0–98.1)

 ≥7.5 %

53.4 (49.2–57.6)

124

17

1

2

7

7

87.9 (81.0–92.7)

28.7 (24.4–33.3)

53.9 (49.2–58.5)

95.5 (92.7–97.3)