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Table 4 Pre-pregnancy maternal BMI, weight gain during pregnancy, and newborn telomere length

From: Maternal pre-pregnancy body mass index and newborn telomere length

 

Cord blood (n = 743)

Placenta (n = 702)

Percentage change (95 % CI)

P value

Percentage change (95 % CI)

P value

Weight gain continuous

 BMI, +1 kg/m2

−0.51 (−0.85 to −0.17)

0.003

−0.64 (−1.06 to −0.23)

0.002

 Weight gain, +5.6 kg

−0.25 (−1.69 to 1.20)

0.73

0.20 (−1.59 to 2.02)

0.83

Weight gain categorical

 BMI, +1 kg/m2

−0.51 (−0.84 to −0.17)

0.003

−0.68 (−1.09 to −0.27)

0.001

 Sufficient

Ref

 

Ref

 

 Insufficient

2.07 (−1.77 to 6.07)

0.29

3.01 (−1.77 to 8.03)

0.22

 Excessive

1.55 (−1.58 to 4.78)

0.33

2.39 (−1.46 to 6.38)

0.23

  1. Models adjusted according to model B (Table 2). Estimates are presented as a percentage change in average relative telomere length for each kg/m2 BMI increase or for a SD increase in weight gain during pregnancy. Categorical weight gain defined according to the Institute of Medicine guidelines [48]. Insufficient and excessive gestational weight gain in relation to maternal pre-pregnancy BMI (for underweight: total weight gain < 13 and > 18 kg; normal weight: total weight gain < 11.5 and > 16.0 kg; for overweight: total weight gain < 7.0 and > 11.5 kg; for obesity: total weight gain < 5.0 and > 9.0 kg, respectively)
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BMC Medicine

ISSN: 1741-7015

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