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Table 4 Pre-pregnancy maternal BMI, weight gain during pregnancy, and newborn telomere length

From: Maternal pre-pregnancy body mass index and newborn telomere length

  Cord blood (n = 743) Placenta (n = 702)
Percentage change (95 % CI) P value Percentage change (95 % CI) P value
Weight gain continuous
 BMI, +1 kg/m2 −0.51 (−0.85 to −0.17) 0.003 −0.64 (−1.06 to −0.23) 0.002
 Weight gain, +5.6 kg −0.25 (−1.69 to 1.20) 0.73 0.20 (−1.59 to 2.02) 0.83
Weight gain categorical
 BMI, +1 kg/m2 −0.51 (−0.84 to −0.17) 0.003 −0.68 (−1.09 to −0.27) 0.001
 Sufficient Ref   Ref  
 Insufficient 2.07 (−1.77 to 6.07) 0.29 3.01 (−1.77 to 8.03) 0.22
 Excessive 1.55 (−1.58 to 4.78) 0.33 2.39 (−1.46 to 6.38) 0.23
  1. Models adjusted according to model B (Table 2). Estimates are presented as a percentage change in average relative telomere length for each kg/m2 BMI increase or for a SD increase in weight gain during pregnancy. Categorical weight gain defined according to the Institute of Medicine guidelines [48]. Insufficient and excessive gestational weight gain in relation to maternal pre-pregnancy BMI (for underweight: total weight gain < 13 and > 18 kg; normal weight: total weight gain < 11.5 and > 16.0 kg; for overweight: total weight gain < 7.0 and > 11.5 kg; for obesity: total weight gain < 5.0 and > 9.0 kg, respectively)