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Table 2 Change in main outcomes compared to baseline within and between groups

From: Effects of testosterone treatment on body fat and lean mass in obese men on a hypocaloric diet: a randomised controlled trial

  Testosterone group
n = 49
Placebo group
n = 51
Difference between groupsa P valueb
Fat mass, kg
 Week 0–10 –7.9 (–9.7 to –6.1)* –7.5 (–9.4 to –5.7)* –0.4 (–3.0 to 2.2) 0.78
 Week 0–56 –9.4 (–11.3 to –7.5)* –6.5 (–8.5 to –4.5)* –2.9 (–5.7 to –0.2) 0.04
Fat mass, %
 Week 0–10 –3.8 (–4.9 to –2.6)* –3.0 (–4.3 to –1.8)* –0.7 (–2.4 to 1.0) 0.40
 Week 0–56 –5.7 (–6.9 to –4.5)* –2.9 (–4.3 to –1.6)* –2.8 (–4.6 to –1.0) 0.003
Lean mass, kg
 Week 0–10 –3.9 (–5.3 to –2.6)* –4.8 (–6.2 to –3.5)* 0.9 (–1.0 to 2.8) 0.36
 Week 0–56 –0.6 (–2.0 to 0.8) –4.0 (–5.5 to –2.5)* 3.4 (1.3 to 5.5) 0.002
VAT area, mm2
 Week 0–10 –7688 (–9333 to –6044)* –6590 (–8267 to –4912)* –1099 (–3448 to 1251) 0.36
 Week 0–56 –7223 (–8921 to –5526)* –4545 (–6383 to –2708)* –2678 (–5180 to –176) 0.04
Body weight, kg
 Week 0–10 –12.0 (–14.5 to –9.5)* –13.5 (–16.0 to –11.0)* 1.5 (–2.0 to 5.1) 0.40
 Week 0–56 –11.4 (–13.9 to –8.8)* –10.9 (–13.6 to –8.1)* –0.5 (–4.3 to 3.3) 0.80
  1. Data are mean (95 % CI)
  2. aDifference between groups (mean adjusted difference) refers to the change over time across groups (linear mixed effects model)
  3. bP value refers to the overall significance of the change between groups during follow-up
  4. *P < 0.05 within group
  5. VAT visceral abdominal tissue