Table 2 Change in main outcomes compared to baseline within and between groups

 Week 0–10

–7.9 (–9.7 to –6.1)^*

–7.5 (–9.4 to –5.7)^*

–0.4 (–3.0 to 2.2)

0.78

 Week 0–56

–9.4 (–11.3 to –7.5)^*

–6.5 (–8.5 to –4.5)^*

–2.9 (–5.7 to –0.2)

0.04

 Week 0–10

–3.8 (–4.9 to –2.6)^*

–3.0 (–4.3 to –1.8)^*

–0.7 (–2.4 to 1.0)

0.40

 Week 0–56

–5.7 (–6.9 to –4.5)^*

–2.9 (–4.3 to –1.6)^*

–2.8 (–4.6 to –1.0)

0.003

 Week 0–10

–3.9 (–5.3 to –2.6)^*

–4.8 (–6.2 to –3.5)^*

0.9 (–1.0 to 2.8)

0.36

 Week 0–56

–0.6 (–2.0 to 0.8)

–4.0 (–5.5 to –2.5)^*

3.4 (1.3 to 5.5)

0.002

 Week 0–10

–7688 (–9333 to –6044)^*

–6590 (–8267 to –4912)^*

–1099 (–3448 to 1251)

0.36

 Week 0–56

–7223 (–8921 to –5526)^*

–4545 (–6383 to –2708)^*

–2678 (–5180 to –176)

0.04

 Week 0–10

–12.0 (–14.5 to –9.5)^*

–13.5 (–16.0 to –11.0)^*

1.5 (–2.0 to 5.1)

0.40

 Week 0–56

–11.4 (–13.9 to –8.8)^*

–10.9 (–13.6 to –8.1)^*

–0.5 (–4.3 to 3.3)

0.80