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Table 2 Summary of enrichment analysis for the top 1494 differentially expressed genes between groups I, II (SVZ+) versus III, IV (SVZ–) (p < 0.05)

From: Spatial transcriptome analysis reveals Notch pathway-associated prognostic markers in IDH1 wild-type glioblastoma involving the subventricular zone

MetaCoreTM process network Upregulated in SVZ+ (n = 771) Downregulated in SVZ+ (n = 723)
Term p value (nupregulated/ntotal) p value (ndownregulated/ntotal)
Blood vessel morphogenesis 0.669 (4/228) 1.55E-04 (16/228)
Regulation of epithelial-to-mesenchymal transition 0.943 (2/226) 4.57E-04 (15/226)
Leukocyte chemotaxis 0.985 (1/205) 5.32E-04 (14/205)
Chromatin modification 9.61E-04 (9/128) 0.392 (4/128)
T cell receptor signaling 0.971 (1/174) 1.22E-03 (12/174)
Cytoskeleton - actin filaments 0.465 (4/176) 1.35E-03 (12/176)
Notch signaling 0.507 (5/236) 2.08E-03 (14/236)
0.480 (4/144)
Skeletal muscle development 2.19E-03 (9/144)
Cell cycle G1/S 0.407 (4/163) 2.31E-03 (11/163)
Inflammation - IL-2 signaling 0.878 (1/104) 4.11E-03 (8/104)
  1. The top 10 enrichments according to p value are depicted (in bold: p < 0.01). In addition, the total number of genes per process network (ntotal) as well as the intersect with significantly up- or downregulated genes are displayed (nupregulated and ndownregulated)