Skip to main content

Table 3 Summary of enrichment analysis for the top 1573 differentially expressed genes between groups II and III (p < 0.05)

From: Spatial transcriptome analysis reveals Notch pathway-associated prognostic markers in IDH1 wild-type glioblastoma involving the subventricular zone

MetaCoreTM process network Upregulated in group II (n = 957) Downregulated in group II (n = 616)
Term p value (nupregulated/ntotal) p value (ndownregulated/ntotal)
Blood vessel morphogenesis 0.058 (10/228) 2.14E-07 (20/228)
Muscle contraction 1.22E-03 (12/173) 0.411 (7/173)
Male sex differentiation 0.087 (10/246) 1.50E-03 (14/246)
Transmission of nerve impulse 2.36E-03 (13/212) 0.360 (6/212)
Neurogenesis 2.95E-03 (12/192) 0.452 (5/192)
Chemotaxis 0.669 (3/137) 4.13E-03 (9/137)
Anti-apoptosis via PI3K/Akt 0.982 (2/233) 7.16E-03 (12/233)
Leukocyte chemotaxis 0.891 (3/205) 7.36E-03 (11/205)
Neurohormone signaling 0.273 (7/211) 9.06E-03 (11/211)
Inflammation - IL-2 signaling 0.482 (3/104) 9.73E-03 (7/104)
  1. The top 10 enrichments according to p value are depicted (in bold: p < 0.01). In addition, the total number of genes per process network (ntotal) as well as the intersect with significantly up- or downregulated genes are displayed (nupregulated and ndownregulated)
  2. PI3K phosphatidylinositide 3-kinase, Akt protein kinase B