Primary mode of action at receptor ending | Primary reason for withdrawal | Median interval between launch and first ADR report | Median interval between first ADR report and withdrawal | Statistical comparisonsa |
---|---|---|---|---|
Neurotransmitter re-uptake inhibition (n = 8) | Cardiotoxicity: n = 7 Drug misuse: n = 1 | 5.5 years (IQR = 1.3 to 13.3 years | 1 year (IQR = 0 to 12 years) | Withdrawal due to cardiotoxicity significantly more likely vs neurotransmitter releasers (P = 0.0004) |
Neurotransmitter release (n = 14) | Cardiotoxicity: n = 1 Drug abuse or dependence: n = 12 Hemorrhagic stroke: n = 1 | 17.5 years (IQR = 5.8 to 28 years) | 5 years (IQR = 2 to 16.3 years) | Withdrawal due to drug misuse significantly more likely vs neurotransmitter re-uptake inhibitors (P = 0.002) |