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Table 3 Estimates of lifetime costs, effects and cost-effectiveness for different extrapolation assumptions

From: Cost-effectiveness of screening for ovarian cancer amongst postmenopausal women: a model-based economic evaluation

Separate parametric models No screening MMS USS
 Costs £143 £588 £782
(95% confidence interval) (£121 to £169) (£425 to £745) (£526 to £1110)
 QALYs 14.352 14.376 14.361
(95% confidence interval) (5.100 to 15.922) (5.108 to 15.95) (5.095 to 15.941)
ICER per QALY £18,372 vs no screening Dominated by MMS
(95% confidence interval) (£7709 to £96,784)
 Life years 24.743 24.820 24.818
(95% confidence interval) (24.706 to 24.771) (24.789 to 24.840) (24.786 to 24.839)
 Ovarian cancer deaths 1.99% 1.04% 1.05%
(95% confidence interval) (1.65% to 2.45%) (0.85% to 1.34%) (0.87% to 1.37%)
Same parametric models No screening MMS USS
 Costs £128 £587 £780
(95% confidence interval) (£109 to £149) (£427 to £745) (£520 to £1105)
 QALYs 14.343 14.356 14.341
(95% confidence interval) (5.174 to 15.933) (5.176 to 15.949) (5.166 to 15.94)
 ICER per QALY £36,769 vs no screening Dominated by MMS
(95% confidence interval) (£13,888 to dominated)
 Life years 24.778 24.821 24.818
(95% confidence interval) (24.751 to 24.797) (24.789 to 24.84) (24.787 to 24.838)
Ovarian cancer deaths 1.49% 1.03% .05%
(95% confidence interval) (1.29% to 1.77%) (0.85% to 1.35%) (0.86% to 1.36%)
Model discrepancy; 5% per year No screening MMS USS
 Costs £179 £614 £851
(95% confidence interval) (£136 to £235) (£440 to £784) (£578 to £1194)
 QALYs 14.209 14.244 14.194
(95% confidence interval) (4.671 to 15.903) (4.66 to 15.954) (4.622 to 15.914)
 ICER per QALY £12,643 vs no screening Dominated by MMS
(95% confidence interval) (£3734 to dominated)
 Life years 24.659 24.800 24.722
(95% confidence interval) (24.548 to 24.739) (24.591 to 24.863) (24.417 to 24.801)
 Ovarian cancer deaths 3.22% 1.99% 3.42%
(95% confidence interval) (2.02% to 5.08%) (0.70% to 4.73%) (1.37% to 7.59%)
  1. ICER incremental cost-effectiveness ratio, QALYs quality-adjusted life years