| |
Premenopausal
|
Perimenopausal
|
Naturally postmenopausal
|
Surgically postmenopausal
|
|---|
|
n = 39,397
|
n = 8669
|
n = 14,514
|
n = 904
|
|---|
|
Baseline
|
|
Age, years
|
36.9 ± 8.1
|
45.0 ± 8.1
|
55.3 ± 7.4
|
52.7 ± 8.1
|
|
Age range, years
|
18–60
|
18–62
|
18–65
|
21-65
|
|
Current hormonal contraception use
|
18,526 (47.6)
|
1938 (22.7)
|
1787 (12.6)
|
825 (2.6)
|
|
Current smoker
|
8125 (21.0)
|
1969 (22.9)
|
2751 (19.1)
|
165 (18.4)
|
|
Antihypertensive medications
|
1559 (4.0)
|
608 (7.0)
|
2356 (20.3)
|
182 (20.3)
|
|
Lipid-lowering medications
|
388 (1.0)
|
178 (2.1)
|
1222 (8.4)
|
92 (10.2)
|
|
Ever HT use
|
203 (0.5)a
|
275 (3.2)
|
1315 (9.1)
|
253 (28.4)
|
|
Outcome
|
|
BMI, kg/m2
|
25.2 ± 4.6
|
26.0 ± 4.9
|
26.2 ± 4.5
|
27.3 ± 5.0
|
|
SBP, mmHg
|
119 ± 13
|
121 ± 14
|
125 ± 16
|
126 ± 16
|
|
DBP, mmHg
|
71 ± 9
|
72 ± 9
|
73 ± 9
|
72 ± 9
|
|
TC, mmol/L
|
4.7 ± 0.8
|
5.0 ± 0.9
|
5.6 ± 1.0
|
5.5 ± 1.0
|
|
LDL-c, mmol/L
|
2.9 ± 0.8
|
3.1 ± 0.8
|
3.6 ± 0.9
|
3.5 ± 0.9
|
|
HDL-c, mmol/L
|
1.6 ± 0.4
|
1.6 ± 0.4
|
1.7 ± 0.4
|
1.6 ± 0.4
|
|
TG, mmol/L
|
1.0 ± 0.5
|
1.0 ± 0.6
|
1.1 ± 0.6
|
1.2 ± 0.7
|
|
Glucose, mmol/L
|
4.8 ± 0.6
|
4.9 ± 0.7
|
5.0 ± 0.8
|
5.1 ± 1.0
|
- Values given in mean ± SD or n (%)
-
aAll reported a currently regular cycle
-
HT hormone replacement therapy, BMI body mass index, SBP systolic blood pressure; DBP diastolic blood pressure, TC total cholesterol, LDL-c low-density lipoprotein cholesterol, HDL-c high-density lipoprotein cholesterol, TG triglycerides
