Table 2 Subgroup analyses after stratification for mean age, population, geographic area, and follow-up length

Mean age

0.37

0.19

0.24

 ≤75

7

3.54 (2.81–4.46)

0

8

2.40 (1.97–2.93)

0

8

1.65 (1.27–2.16)

59

 >75

8

3.12 (2.67–3.65)

0

9

2.04 (1.79–2.33)

0

9

1.38 (1.22–1.57)

0

Population

0.36

0.32

0.91

 General population

10

3.27 (2.86–3.75)

0

11

2.22 (1.98–2.49)

0

11

1.48 (1.32–1.65)

9

 Outpatients

2

2.53 (1.56–4.12)

0

3

1.45 (0.83–2.52)

14

3

1.48 (0.54–4.08)

80

 Hospitalized

3

4.93(2.18–11.14)

0

3

1.94 (0.85–4.41)

0

3

1.23 (0.53–2.85)

0

Geographic area

0.40

0.24

0.37

 Europe

11

3.44 (2.91–4.07)

0

11

2.02 (1.74–2.33)

3

11

1.42 (1.25–1.60)

0

 Asia

1

1.15(0.13–10.54)

–

1

3.94(1.34–11.56)

–

1

1.95 (0.82–4.63)

–

 North America

3

3.01(2.46–3.69)

0

5

2.34 (1.96–2.80)

0

5

1.79 (1.26–2.55)

73

Follow-up length

0.49

0.30

0.94

 ≤1 year

3

4.22 (1.97–9.02)

0

4

1.42 (0.65–3.10)

0

4

1.51 (0.50–4.59)

64

 >1 year

12

3.22 (2.83–3.69)

0

13

2.16 (1.94–2.41)

0

13

1.45 (1.32–1.60)

0

0.72

0.77

0.84

 ≤5 years

10

3.30 (2.82–3.86)

0

11

2.13 (1.86–2.43)

0

11

1.53 (1.23–1.91)

49

 >5 years

5

3.13 (2.48–3.96)

5

6

2.22 (1.73–2.85)

35

6

1.49 (1.27–1.75)

0