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Table 3 SNPs found to be significantly associated with AMY1 or AMY2 plasma enzymatic activity in D.E.S.I.R. participants, with a replication study in ABOS participants

From: Relationship between salivary/pancreatic amylase and body mass index: a systems biology approach

  SNP ID Chr: position (Build 37) Closest gene Tested allele/Other allele Cohort study n MAF Effect size ± SE per allele P value
AMY1 rs10492100 12:11085820 PRH1-PRR4 C / T Discovery 3673 0.21 −2.36 ± 0.39 6.6 × 10−10
Replication 488 0.25 −2.31 ± 0.85 6.9 × 10−3
Meta-analysis 4227 −2.35 ± 0.35 3.3 × 10−11
AMY2 rs12075225 1:104115017 AMY2B A / C Discovery 3905 0.10 5.11 ± 0.29 3.3 × 10−70
Replication 488 0.07 3.48 ± 1.04 9.1 × 10−4
Meta-analysis 4227 4.99 ± 0.28 2.0 × 10−71
AMY2 rs507666 9:136149399 ABO A / G Discovery 3905 0.22 −1.17 ± 0.22 5.7 × 10−8
Replication 488 0.21 −1.21 ± 0.60 4.4 × 10−2
Meta-analysis 4227 −1.17 ± 0.21 1.3 × 10−8
  1. AMY1 salivary amylase, AMY2 pancreatic amylase, Chr chromosome, MAF minor allele frequency, SE standard error