Skip to main content

Advertisement

Table 4 Circulating concentrations of osteoprotegerin and breast cancer risk by age at diagnosis: EPIC cohort breast cancer nested case-control study

From: Osteoprotegerin and breast cancer risk by hormone receptor subtype: a nested case-control study in the EPIC cohort

  Tertiles     
1 2 3     
Cut points (ng/mL) <0.18 0.18 - <0.22 ≥0.22 p trend a RRlog2 b p het c p het d
Age at diagnosis
 <50 yearse
  ER+/PR+
   Cases/controls 82/70 25/35 13/15     
   RR (95% CI) Ref. 0.48 (0.23-0.98) 0.53 (0.17-1.69) 0.14 0.48 (0.18-1.28)   
  ER+
   Cases/controls 99/87 27/40 17/16     
   RR (95% CI) Ref. 0.49 (0.25-0.96) 0.79 (0.30-2.09) 0.32 0.64 (0.26-1.54)   
 ≥50 years
  ER+/PR+
   Cases/controls 260/242 272/273 277/294     
   RR (95% CI) Ref. 0.90 (0.69-1.18) 0.86 (0.64-1.16) 0.47 0.89 (0.65-1.22) 0.02 0.53
  ER+        
   Cases/controls 460/423 492/504 527/552     
   RR (95% CI) Ref. 0.87 (0.71-1.06) 0.85 (0.68-1.06) 0.24 0.87 (0.68-1.10) 0.02 0.72
  ER–/PR–        
   Cases/controls 58/71 71/90 95/63     
   RR (95% CI) Ref. 1.15 (0.65-2.02) 2.54 (1.35-4.77) 0.02 2.21 (1.11-4.40)   0.30
  ER–        
   Cases/controls 101/119 103/112 123/96     
   RR (95% CI) Ref. 1.21 (0.77-1.92) 1.90 (1.17-3.09) 0.04 1.76 (1.03-3.01)   0.62
  1. Conditional logistic regression models adjusted for ages at menarche (≤12, 13, 14, ≥15, missing), menopause (<44, 44-47, 48-50, 51-52, 53-54, ≥55, missing), first full-term pregnancy (no FTP, <25, 25-30, ≥30, missing), number of full-term pregnancies (0, 1, 2, ≥3, missing), and BMI (kg/m2, continuous)
  2. a p trend based on log2-transformed continuous variable
  3. bRR for a one-unit change in log2-transformed OPG
  4. c p heterogeneity comparing ER+/PR+ to ER–/PR– and ER+ to ER– subtypes, based on RRlog2
  5. d p heterogeneity comparing age at diagnosis <50 to 50+ years based on RRlog2
  6. eAge at diagnosis results limited to ER+/PR+ and ER+ cases given n = 34 ER–/PR– cases; n = 59 ER– cases in this subgroup