Pathway (total number of genes in pathway) | Observed/Expected number of genes | P value | q value |
---|---|---|---|
Non-obese subjects | |||
 Pathways in cancer (325) | 321/295 | 9.8 × 10−10 | 2.2 × 10−7 |
 Metabolic pathways (1112) | 1060/1009 | 3.3 × 10−9 | 3.7 × 10−7 |
 Focal adhesion (200) | 199/182 | 7.6 × 10−8 | 4.3 × 10−6 |
 Endocytosis (200) | 199/182 | 7.6 × 10−8 | 4.3 × 10−6 |
 MAPK signaling pathway (267) | 260/242 | 1.4 × 10−5 | 5.0 × 10−4 |
 Ubiquitin mediated proteolysis (134) | 133/122 | 3.3 × 10−5 | 1.1 × 10−3 |
 Neurotrophin signaling pathway (127) | 126/115 | 6.2 × 10−5 | 1.8 × 10−3 |
 Protein processing in endoplasmic reticulum (165) | 162/150 | 1.0 × 10−4 | 1.8 × 10−3 |
 Lysosome (121) | 120/110 | 1.0 × 10−4 | 1.8 × 10−3 |
 Cell cycle (124) | 123/113 | 8.1 × 10−5 | 1.8 × 10−3 |
 Oxidative phosphorylation (119) | 118/108 | 1.0 × 10−4 | 1.8 × 10−3 |
 Regulation of actin cytoskeleton (211) | 205/192 | 2.0 × 10−4 | 2.9 × 10−3 |
 TGF-beta signaling pathway (84) | 84/76 | 3.0 × 10−4 | 3.8 × 10−3 |
 Axon guidance (129) | 127/117 | 4.0 × 10−4 | 4.8 × 10−3 |
 Phosphatidylinositol signaling system (78) | 78/71 | 5.0 × 10−4 | 5.7 × 10−3 |
 Purine metabolism (162) | 158/147 | 6.0 × 10−4 | 6.5 × 10−3 |
 Calcium signaling pathway (176) | 171/160 | 8.0 × 10−4 | 7.9 × 10−3 |
 Pyrimidine metabolism (98) | 97/89 | 8.0 × 10−4 | 7.9 × 10−3 |
 Adipocytokine signaling pathway (68) | 68/62 | 1.4 × 10−3 | 1.3 × 10−2 |
 p53 signaling pathway (68) | 68/62 | 1.4 × 10−3 | 1.3 × 10−2 |
 Wnt signaling pathway (149) | 145/135 | 1.5 × 10−3 | 1.3 × 10−2 |
 ErbB signaling pathway (87) | 86/79 | 2.1 × 10−3 | 1.7 × 10−2 |
 Melanogenesis (101) | 99/92 | 3.5 × 10−3 | 2.6 × 10−2 |
 Inositol phosphate metabolism (57) | 57/52 | 4.0 × 10−3 | 2.9 × 10−2 |
 Peroxisome (79) | 78/72 | 4.3 × 10−3 | 3.0 × 10−2 |
 mTOR signaling pathway (52) | 52/47 | 6.5 × 10−3 | 4.2 × 10−2 |
 Spliceosome (127) | 123/115 | 7.0 × 10−3 | 4.4 × 10−2 |
Obese subjects | |||
 Pathways in cancer (325) | 325/311 | 4.3 × 10−7 | 9.8 × 10−5 |
 Metabolic pathways (1112) | 1086/1063 | 2.0 × 10−4 | 2.3 × 10−2 |