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Table 3 Impact of neoadjuvant chemotherapy on healthy tissue (PP)

From: Metabolomics approaches in pancreatic adenocarcinoma: tumor metabolism profiling predicts clinical outcome of patients

Metabolite Neoadjuvant chemotherapy Mean (nmol/mg) p value
Ascorbate No 0.3488 ± 0.2191 0.6730
Yes 0.3592 ± 0.1671
Aspartic acid No 0.7577 ± 0.3284 0.9626
Yes 0.6730 ± 0.1776
Choline No 1.5580 ± 0.5921 0.7430
Yes 1.7649 ± 0.7624
Creatine No 1.7371 ± 0.9568 0.5414
Yes 1.7760 ± 0.6579
Ethanolamine No 0.9314 ± 0.4502 0.6058
Yes 1.1115 ± 0.5408
Glutamate No 2.9830 ± 0.8698 0.8148
Yes 2.3800 ± 0.4264
Glycerol No 8.1840 ± 7.3988 0.6730
Yes 8.2990 ± 7.2904
Glycine No 6.0920 ± 5.0908 0.5414
Yes 6.5590 ± 5.7401
Glycerophosphocholine No 2.4215 ± 2.6084 0.9626
Yes 2.2208 ± 2.1689
Lactate No 11.0040 ± 2.4733 0.3704
Yes 9.6770 ± 2.1588
Phosphorylcholine No 1.1690 ± 0.6396 0.8148
Yes 0.9469 ± 0.3644
Taurine No 2.9660 ± 1.9594 0.9626
Yes 2.7060 ± 1.3103
Threonine No 1.1202 ± 0.2821 0.6730
Yes 1.1678 ± 0.2801
Glutamine No 0.6855 ± 0.2518 0.5414
Yes 0.5633 ± 0.1466
Succinic acid No 0.3069 ± 0.2121 0.8884
Yes 0.2595 ± 0.1406
Glucose No 1.2247 ± 0.6158 0.4807
Yes 1.0736 ± 0.7355
Tyrosine No 0.0520 ± 0.0442 0.6058
Yes 0.0552 ± 0.0599
Phenylalanine No 0.1449 ± 0.0771 0.8148
Yes 0.1495 ± 0.0880
  1. Results of the Mann-Whitney U test. Metabolite differences between PP without neoadjuvant chemotherapy and PP with neoadjuvant chemotherapy (univariate analysis, nonparametric test)