| Multivariable adjusted (Model 3) | Multivariable adjusted (Model 4) |
---|
HR (95% CI) |
P value | HR (95% CI) |
P value |
---|
Allopurinol use |
0.82 (0.75–0.89)
|
< 0.0001
| – | – |
Allopurinol use durationa
|
 0 days (non-use) | – | – | Ref |  |
 1–180 days | – | – | 0.92 (0.82–1.04) | 0.18 |
 181 days to 2 years | – | – |
0.76 (0.68–0.84)
|
< 0.0001
|
  > 2 years | – | – |
0.78 (0.65–0.94)
|
0.009
|
-
aBased on person day count
- Model 3 = Allopurinol use + age + race + sex + beta blockers + diuretics + ACE inhibitors + statins + CAD + cardiomyopathy + heart failure + congenital heart disease + valvular heart disease + renal failure + dialysis + sarcoidosis + hyperkalemia
- Model 4 = Allopurinol duration + age + race + sex + beta blockers + diuretics + ACE inhibitors + statins + CAD + cardiomyopathy + heart failure + congenital heart disease + valvular heart disease + renal failure + dialysis + sarcoidosis + hyperkalemia
- Significant hazards ratios and P values are in bold
-
HR hazard ratio, CI confidence interval, Ref referent category