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Table 3 Sensitivity Analysis 1: Association of risk factors with hazard of ventricular arrhythmias adjusted for specific disease risk factors for ventricular arrhythmias instead of Charlson index

From: Allopurinol and the risk of ventricular arrhythmias in the elderly: a study using US Medicare data

  Multivariable adjusted (Model 3) Multivariable adjusted (Model 4)
HR (95% CI) P value HR (95% CI) P value
Allopurinol use 0.82 (0.75–0.89) < 0.0001
Allopurinol use durationa
 0 days (non-use) Ref  
 1–180 days 0.92 (0.82–1.04) 0.18
 181 days to 2 years 0.76 (0.68–0.84) < 0.0001
  > 2 years 0.78 (0.65–0.94) 0.009
  1. aBased on person day count
  2. Model 3 = Allopurinol use + age + race + sex + beta blockers + diuretics + ACE inhibitors + statins + CAD + cardiomyopathy + heart failure + congenital heart disease + valvular heart disease + renal failure + dialysis + sarcoidosis + hyperkalemia
  3. Model 4 = Allopurinol duration + age + race + sex + beta blockers + diuretics + ACE inhibitors + statins + CAD + cardiomyopathy + heart failure + congenital heart disease + valvular heart disease + renal failure + dialysis + sarcoidosis + hyperkalemia
  4. Significant hazards ratios and P values are in bold
  5. HR hazard ratio, CI confidence interval, Ref referent category