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Table 3 The effect of the intervention (disease management versus usual care) on the primary endpoint and its components

From: Disease management in the treatment of patients with chronic heart failure who have universal access to health care: a randomized controlled trial

Endpoint Crude hazard ratio (95% confidence interval) Adjusted hazard ratioa (95% confidence interval) (model 1) Adjusted hazard ratioa (95% confidence interval) (models 2, 3)
Time to first hospital admission for heart failure or death from all causes (primary composite outcome) 0.981 (0.852 to 1.129) 0.908 (0.788 to 1.047)
Time to death from all causes 1.060 (0.881 to 1.275) 0.982 (0.814 to 1.185) 0.997 (0.820 to 1.213) (Model 2)
Time to first hospital admission for heart failure 0.909 (0.777 to 1.063) 0.846 (0.722 to 0.991) 0.832 (0.708 to 0.977) (Model 3)
  1. NYHA New York Heart Association
  2. aCox proportional hazard models were adjusted for
  3. Model 1: Sex, study center, baseline age, NYHA classification and 6-minute walk test
  4. Model 2: All covariates included in model 1 plus source of recruitment, body mass index, renal failure and hemoglobin
  5. Model 3: All covariates included in model 1 plus source of recruitment, main underlying cause of heart failure, baseline renal failure and hemoglobin
  6. Renal failure was defined as an estimated glomerular filtration rate less than 60 mL/min/1.73 m2