Table 1 Clinical characteristics of cohorts studied

Number of patients

44

22

22

Age, median (range)^a

66.5 (38.2–79.3)

64.5 (44–78)

67.5 (38.2–79.3)

 Median

16.2

23.5

12.3

 Interquartile range

9.1–25.9

14.8–29.8

7.6–18.8

 Number censored

22

10

12

 Modes (bimodal model)

10.6, 27.3

10.2, 27.4

11.6, 27.5

Number of samples per tumour^a median (range)

4 (1–10)

4 (1–10)

4 (2–8)

Male gender^b

29

15

14

 4

9

1

8

 3

22

12

10

 2

13

9

4

 T4

4

4

0

 T3

33

13

20

 T2

6

4

2

 T1

1

1

0

 KPS >80 (unavailable)

34 (1)

13 (0)

21 (1)

Anaemia^{b ,+} (unavailable)

22 (2)

12 (0)

10 (2)

Raised calcium^b (unavailable)

8 (7)

5 (0)

3 (7)

Raised LDH^c (unavailable)

10 (15)

5 (0)

5 (15)

Neutrophil count >70% upper limit of normal^b (unavailable)

9 (2)

2 (0)

7 (2)

Platelet count >400^b (unavailable)

12 (2)

6 (0)

6 (2)

VHL mutation^b

31

14

17

 Partial response

–

2

–

 Stable disease

–

20

–

 1

19

6

13

 2

18

11

7

 3

7

5

2

 Intermediate

26

12

14

 Poor

16

10

6

 Unavailable

2

0

2

 Favourable/intermediate:

26

13

13

 Poor

12

9

3

 Unavailable

6

0

6