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Table 1 Baseline characteristics for patients with a LN yield < 10 vs. ≥ 10

From: The prognostic value of lymph node yield in the earliest stage of colorectal cancer: a multicenter cohort study

  Baseline characteristics original cohort Baseline characteristics LN yield < 10 vs. ≥ 10
    Unadjusted dataa IPW adjusted data for the confounders considered for the primary analysisa,c IPW adjusted data for the confounders considered for the secondary supporting analysisa,d
  N = 1017a Missing (%)b LN yield < 10 N = 612 LN yield
≥ 10 N = 405
P value LN yield
< 10 N = 612
LN yield ≥ 10 N = 405 P value LN yield
< 10 N = 612
LN yield ≥ 10 N = 405 P value
Age in years 69.1 0.5 68.6 69.7 0.07 69.1 69.0 0.47 69.1 69.1 0.74
Male sex 54.6 0 55.7 52.8 0.40 54.6 54.0 0.30 54.5 53.7 0.35
BMI in kg/m2 26.9 27.9 26.9 27.0 0.70 26.8 27.0 0.54 26.7 27.1 0.46
ASA score   0.4          
 - ASA I
 - ASA II
 - ASA III–IV
29.7
49.5
20.8
31.6
47.5
20.9
26.9
52.3
20.7
0.13
0.15
0.99
30.3
47.8
21.8
29.0
52.0
18.9
0.67
0.20
0.24
30.1
48.0
21.9
29.1
51.8
19.0
0.79
0.25
0.25
Tumor location   0          
 - Right colon
 - Left colon
 - Rectum
24.1
58.8
17.1
15.2
68.6
16.2
37.5
44.0
18.5
<0.001
<0.001
0.38
24.2
58.7
17.0
24.1
58.8
17.1
0.62
0.89
0.67
23.9
59.0
17.1
23.9
58.9
17.2
0.84
0.83
0.85
Tumor morphology   5.0          
 - Pedunculated
 - Non-pedunculated
33.4
66.6
39.3
60.7
24.1
75.9
<0.001
<0.001
33.3
66.7
33.7
66.3
0.39
0.39
33.4
66.6
33.7
66.3
0.68
0.68
Tumor size in cm 2.7 9.4 2.6 2.9 0.003 2.7 2.7 0.82 2.7 2.7 0.82
Lymph node metastasis 8.3 0 6.0 11.6 0.002 8.6 8.5 0.91 8.3 8.4 0.75
Adjuvant chemotherapy 4.4 0 3.6 5.7 0.15 4.6 4.5 0.92 4.4 4.6 0.82
Lymphovascular invasion   53.8          
 - Absent
 - Present
79.2
20.8
70.1
29.9
79.8
20.2
0.04
0.04
69.7
30.3
78.9
21.1
0.03
0.03
73.3
26.7
73.2
26.8
0.70
0.70
Differentiation grade   18.5          
 - Well
 - Moderate
 - Poor
14.0
80.6
5.4
14.9
79.4
5.7
12.7
82.3
5.0
0.44
0.31
0.63
15.1
79.6
5.4
12.9
82.0
5.1
0.47
0.41
0.59
14.1
80.6
5.3
14.2
80.7
5.1
0.71
0.73
0.62
Invasion depth   50.3          
 - Haggitt I/II/III or SM1
 - Haggitt IV or SM2/3
44.9
55.1
47.3
52.7
41.4
58.6
0.21
0.21
43.7
56.3
45.8
54.2
0.67
0.67
44.6
55.4
44.3
55.7
0.83
0.83
  1. ASA American Society of Anesthesiologists, BMI body mass index, cm centimeter, IPW inverse probability weighting, kg kilogram, LN lymph node, m meter
  2. aValues are means for continuous variables and percentages for categorical variables
  3. bPercentage of patients with missing data in the original cohort
  4. cInverse probability weighting was based on age, sex, tumor location, tumor size, tumor morphology and the presence of lymph node metastasis (primary analysis)
  5. dInverse probability weighting was based on age, sex, tumor location, tumor size, tumor morphology, invasion depth, presence of lymphovascular invasion, differentiation grade, and presence of lymph node metastasis (secondary supporting analysis)