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Fig. 1 | BMC Medicine

Fig. 1

From: A 13-gene expression-based radioresistance score highlights the heterogeneity in the response to radiation therapy across HPV-negative HNSCC molecular subtypes

Fig. 1

Overall strategy for the identification of 13 radioresistance-associated genes in human papillomavirus (HPV)-negative head and neck squamous cell carcinoma (HNSCC). Genes associated with HNSCC radioresistance were defined as the overlapping genes between three distinct conditions, namely genes differentially expressed in 86 paired cancer and normal mucosa samples with HNSCC from The Cancer Genome Atlas; genes differentially expressed between 14 radiosensitive and 18 radioresistant HNSCC cell lines from GSE79368; and genes associated with disease-free survival in 128 patients treated for HPV-negative HNSCC from TCGA treated with surgery and radiotherapy. We used a false discovery rate < 0.05 and a |FC| > 1 to select differentially expressed genes. FC fold change, HR hazard ratio

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