Table 1 List of 13 genes differentially expressed in tumor versus normal head and neck mucosa, associated with in vitro and in vivo radioresistance in human papillomavirus (HPV)-negative head and neck squamous cell carcinoma (HNSCC)
Tumor vs. Normal (head neck mucosa) | Radioresistant vs. radiosensitive (HNSCC cell lines) | Association with DFS (patients with HPV-negative HNSCC treated by adjuvant radiotherapy) | |||||
|---|---|---|---|---|---|---|---|
GENE | FC | FDR | FC | FDR | HR | P value | |
CSTF3 | UP | 1.179 | 0.0025 | 1.6031 | 0.0232 | 1.7458 | 0.0300 |
ST3GAL5 | UP | 1.6115 | 0.0083 | 1.9865 | 0.0343 | 1.3127 | 0.0495 |
UFD1L | UP | 1.3426 | <0.0001 | 1.45 | 0.0327 | 1.6790 | 0.0205 |
CCDC60 | DN | –6.5001 | <0.0001 | –1.3095 | 0.0258 | 0.7688 | 0.0244 |
FAM81A | DN | –2.0136 | 0.0003 | –1.7879 | 0.0473 | 0.7772 | 0.0288 |
FGD2 | DN | –1.6559 | 0.0023 | –1.7021 | 0.0464 | 0.7755 | 0.0198 |
HS3ST6 | DN | –2.9678 | 0.0140 | –1.3122 | 0.044 | 0.8869 | 0.0210 |
ITGB7 | DN | –1.3982 | 0.0169 | –2.5899 | 0.0448 | 0.7115 | 0.0050 |
PRR15L | DN | –6.0454 | <0.0001 | –2.29 | 0.0004 | 0.8618 | 0.0362 |
SCGB2A1 | DN | –5.769 | 0.0001 | –1.4528 | 0.0369 | 0.7743 | 0.0490 |
SCNN1A | DN | –4.9431 | <0.0001 | –4.8042 | 0.033 | 0.8432 | 0.0215 |
ST6GALNAC1 | DN | –6.5319 | <0.0001 | –3.2498 | 0.0011 | 0.8826 | 0.0436 |
VILL | DN | –1.8517 | 0.0077 | –2.9028 | 0.0055 | 0.7511 | 0.0337 |