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Table 1 List of 13 genes differentially expressed in tumor versus normal head and neck mucosa, associated with in vitro and in vivo radioresistance in human papillomavirus (HPV)-negative head and neck squamous cell carcinoma (HNSCC)

From: A 13-gene expression-based radioresistance score highlights the heterogeneity in the response to radiation therapy across HPV-negative HNSCC molecular subtypes

   Tumor vs. Normal (head neck mucosa) Radioresistant vs. radiosensitive (HNSCC cell lines) Association with DFS (patients with HPV-negative HNSCC treated by adjuvant radiotherapy)
GENE   FC FDR FC FDR HR P value
CSTF3 UP 1.179 0.0025 1.6031 0.0232 1.7458 0.0300
ST3GAL5 UP 1.6115 0.0083 1.9865 0.0343 1.3127 0.0495
UFD1L UP 1.3426 <0.0001 1.45 0.0327 1.6790 0.0205
CCDC60 DN –6.5001 <0.0001 –1.3095 0.0258 0.7688 0.0244
FAM81A DN –2.0136 0.0003 –1.7879 0.0473 0.7772 0.0288
FGD2 DN –1.6559 0.0023 –1.7021 0.0464 0.7755 0.0198
HS3ST6 DN –2.9678 0.0140 –1.3122 0.044 0.8869 0.0210
ITGB7 DN –1.3982 0.0169 –2.5899 0.0448 0.7115 0.0050
PRR15L DN –6.0454 <0.0001 –2.29 0.0004 0.8618 0.0362
SCGB2A1 DN –5.769 0.0001 –1.4528 0.0369 0.7743 0.0490
SCNN1A DN –4.9431 <0.0001 –4.8042 0.033 0.8432 0.0215
ST6GALNAC1 DN –6.5319 <0.0001 –3.2498 0.0011 0.8826 0.0436
VILL DN –1.8517 0.0077 –2.9028 0.0055 0.7511 0.0337
  1. DN downregulated, FC fold change, FDR false discovery rate, HR hazard ratio, UP upregulated