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Table 2 Incidence rates and hazard ratios (HRs) for associations of fracture with exposure to polymyalgia rheumatica (PMR) and giant cell arteritis (GCA)

From: Risk of fracture among patients with polymyalgia rheumatica and giant cell arteritis: a population-based study

Variables Present Non-present Unadjusted HR (95% CI) Adjusted HR (95% CI)a
  Number with fracture Rate per 10,000 person-years (95% CI) Number with fracture Rate per 10,000 person-years   
PMR
 Overall 1689 148.05 (141.16–155.28) 5173 115.67 (112.56–118.87) 1.29 (1.22–1.36) 1.63 (1.54–1.73)
Sex
 Male 244 68.79 (60.68–77.99) 707 52.07 (48.37–56.06) 1.32 (1.15–1.53) 1.54 (1.33–1.81)
 Female 1445 183.81 (174.57–193.54) 4466 143.4 (139.25–147.67) 1.29 (1.22–1.37) 1.61 (1.52–1.72)
Age in years
 40–50 16 45.58 (27.93–74.41) 48 32.55 (24.53–43.2) 1.40 (0.81–2.41) 1.92 (1.01–3.69)
 50–60 116 81.29 (67.77–97.52) 264 46.04 (40.81–51.94) 1.78 (1.43–2.2) 2.23 (1.79–2.79)
 60–70 357 112.33 (101.26–124.61) 1018 78.56 (73.88–83.53) 1.44 (1.28–1.62) 1.85 (1.56–2.10)
 70–80 753 161.12 (150.01–173.04) 2555 138.51 (133.25–143.99) 1.17 (1.08–1.26) 1.51 (1.38–1.64)
  ≥ 80 447 251.34 (229.08–275.75) 1288 210.89 (199.68–222.72) 1.21 (1.08–1.34) 1.61 (1.43–1.81)
GCA
 Overall 371 147.15 (132.91–162.91) 1142 109.52 (103.35–116.06) 1.36 (1.22–1.53) 1.67 (1.49–1.88)
Sex
 Male 49 66.62 (50.35–88.15) 127 42.37 (35.61–50.42) 1.59 (1.15–2.2) 1.62 (1.17–2.24)
 Female 322 180.31 (161.66–201.12) 1015 136.6 (128.45–145.27) 1.34 (1.19–1.51) 1.67 (1.47–1.90)
Age in years
 40–50 4 35.23 (13.22–93.86) 9 18.87 (9.82–36.26) 1.87 (0.63–5.58) 1.98 (0.66–5.94)
 50–60 18 55.2 (34.78–87.61) 46 34.94 (26.17–46.65) 1.56 (0.9–2.71) 2.27 (1.25–4.15)
 60–70 85 112.74 (91.15–139.45) 257 78.19 (69.19–88.36) 1.49 (1.17–1.89) 1.79 (1.40–2.30)
 70–80 181 185.8 (160.61–214.94) 579 141.96 (130.85–154) 1.34 (1.13–1.57) 1.65 (1.39–1.95)
  ≥ 80 83 234.75 (189.31–291.1) 251 197.88 (174.85–223.94) 1.20 (0.93–1.54) 1.48 (1.13–1.94)
  1. aAdjusted for confounding factors which affected the HR > 10%, from age, sex, BMI, alcohol consumption, smoking status, Charlson comorbidity index and PPI use when not stratified by those