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Table 5 The proposed age-based dosing regimen showing the proportions of individuals who would receive a subtherapeutic, therapeutic or supratherapeutic dose and the corresponding mg base/kg doses of primaquine (PQ)

From: Single low-dose primaquine for blocking transmission of Plasmodium falciparum malaria – a proposed model-derived age-based regimen for sub-Saharan Africa

  PQ dose (mg base) Subtherapeutic dose <0.15 mg/kg, n (%) Therapeutic dose 0.15–0.5 mg/kg, n (%) Supratherapeutic dose >0.5 mg/kg, n (%) Modelled weights by centile (kg) PQ dose by centile (mg base/kg)
      1st Median 99th 1st Median 99th
0.5 to <1 (n = 39,886) 1.25 10,778 (27.0) 29,180 (73.2) 0 5.0 7.6 10.8 0.12 0.16 0.25
1–5 (n = 261,036) 2.5 15,744 (6.0) 244,537 (93.7) 755 (0.3) 6.8 12.0 19.2 0.13 0.21 0.37
6–9 (n = 20,770) 5 80 (0.4) 20,690 (99.6) 0 13.2 20.0 31.2 0.16 0.25 0.38
10–14 (n = 12,155) 7.5 69 (0.6) 12,086 (99.4) 0 20.0 29.0 49.0 0.15 0.26 0.38
≥15 (n = 328,132) 15 469 (0.14) 327,620 (99.8) 43 (0.01) 37.8 55.3 90.2 0.17 0.27 0.40
  1. PQ primaquine