International core outcome set for clinical trials of medication review in multi-morbid older patients with polypharmacy

Table 1 Results of Round 3 of the Delphi survey and of the consensus meetings

Domain	Outcome^a	Delphi survey, Round 3			Consensus meetings
		(% answering YES)^b			Consensus meetings
		Patients	HCPs	Experts	Discussion required before final inclusion	Final decision
Medication use	Unnecessary drugs (overuse)	69	76	97		IN
	Underuse	70	73	83		IN
	Clinically significant drug-drug interaction	100	92	71		IN
	Suitability of drug dosage according to renal function	70	88	57	Yes	Feasibility issue
	Potentially inappropriate medications	55	68	68	Yes	IN
	Measurement of appropriateness	80	60	75	Yes	OUT
	Compliance with medication	62	76	67	Yes	OUT
Use of healthcare resources	Hospitalization (all causes of hospitalization)	62	55	35		OUT
Adverse events	Drug-related hospital admissions	83	86	84		IN
	Adverse drug reaction	70	67	57		OUT
	Serious adverse drug reaction	98	94	77	Yes	Feasibility issue
	Adverse drug withdrawal event	68	68	57		OUT
Patient-reported outcomes	Quality of life	93	71	67		IN
Patient-reported outcomes	Pain relief	89	49	23	Yes	IN
Process evaluation	Elicitation and consideration of patient preference	65	69	56		OUT
	Level of satisfaction of the patient’s GP with communication on medication change	61	65	37		OUT
	Patient’s satisfaction with the information on his/her medication treatment	69	60	62		OUT

ISSN: 1741-7015