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Table 1 Results of Round 3 of the Delphi survey and of the consensus meetings

From: International core outcome set for clinical trials of medication review in multi-morbid older patients with polypharmacy

Domain Outcomea Delphi survey, Round 3 Consensus meetings
(% answering YES)b
Patients HCPs Experts Discussion required before final inclusion Final decision
Medication use Unnecessary drugs (overuse) 69 76 97   IN
Underuse 70 73 83   IN
Clinically significant drug-drug interaction 100 92 71   IN
Suitability of drug dosage according to renal function 70 88 57 Yes Feasibility issue
Potentially inappropriate medications 55 68 68 Yes IN
Measurement of appropriateness 80 60 75 Yes OUT
Compliance with medication 62 76 67 Yes OUT
Use of healthcare resources Hospitalization (all causes of hospitalization) 62 55 35   OUT
Adverse events Drug-related hospital admissions 83 86 84   IN
Adverse drug reaction 70 67 57   OUT
Serious adverse drug reaction 98 94 77 Yes Feasibility issue
Adverse drug withdrawal event 68 68 57   OUT
Patient-reported outcomes Quality of life 93 71 67   IN
Pain relief 89 49 23 Yes IN
Process evaluation Elicitation and consideration of patient preference 65 69 56   OUT
Level of satisfaction of the patient’s GP with communication on medication change 61 65 37   OUT
Patient’s satisfaction with the information on his/her medication treatment 69 60 62   OUT
  1. aBased on the 17 outcomes selected after Round 2
  2. bBoldface indicates ≥ 75% YES ratings
  3. Abbreviation: HCP healthcare provider