Fig. 3

Changes in intra-adrenal steroid levels (ng/mg of tissue) during the second trimester. Data points from individual fetuses are shown (n = 60), and steroids which show a significant change with gestational age are indicated with an asterisk. Levels of pregnenolone (P = 0.004), 17α-hydroxyprogesterone (P < 0.001), 16α-hydroxyprogesterone (P = 0.02) and corticosterone (P < 0.001) decreased from 12 to 19 weeks. Generalized linear regressions are shown as black lines with the corresponding confidence intervals (0.95) in grey