Skip to main content

Table 2 Intra-adrenal steroids measured by LC/MS

From: The human fetal adrenal produces cortisol but no detectable aldosterone throughout the second trimester

   

Total

Control female

Smoke-exposed female

Control male

Smoke-exposed male

Steroid

LOQ (ng/mL MeOH)

LOQ (adjusted)a

QSb (n = 60)

Mean ± SEM (ng/mg tissue)

QS (n = 15)

Mean ± SEM (ng/mg tissue)

QS (n = 15)

Mean ± SEM (ng/mg tissue)

QS (n = 15)

Mean ± SEM (ng/mg tissue)

QS (n = 15)

Mean ± SEM (ng/mg tissue)

Pregnenolone

10

0.05

58

5.019 ± 0.49

15

4.619 ± 0.79

13

4.299 ± 0.927

15

4.073 ± 0.828

15

7.087 ± 1.135

17α-Hydroxyprogesterone

1

0.005

60

1.291 ± 0.182

15

1.086 ± 0.151

15

1.115 ± 0.189

15

0.878 ± 0.159

15

2.087 ± 0.624

DHEAS

0.1

0.0005

60

1.153 ± 0.178

15

1.426 ± 0.412

15

0.782 ± 0.16

15

0.966 ± 0.271

15

1.437 ± 0.468

Progesterone

1

0.005

60

1.089 ± 0.185

15

0.993 ± 0.194

15

0.95 ± 0.278

15

1.066 ± 0.504

15

1.347 ± 0.415

Cortisol

0.1

0.0005

56

0.626 ± 0.087

14

0.713 ± 0.198

14

0.498 ± 0.127

13

0.471 ± 0.142

15

0.824 ± 0.198

Corticosterone

0.1

0.0005

57

0.354 ± 0.075

13

0.265 ± 0.073

14

0.213 ± 0.08

15

0.345 ± 0.153

15

0.593 ± 0.224

16α-Hydroxyprogesterone

0.1

0.0005

59

0.259 ± 0.035

15

0.259 ± 0.036

14

0.18 ± 0.04

15

0.192 ± 0.038

15

0.407 ± 0.116

11-Deoxycortisol

0.1

0.0005

60

0.119 ± 0.017

15

0.148 ± 0.039

15

0.1 ± 0.03

15

0.082 ± 0.02

15

0.146 ± 0.042

Cortisone

1

0.005

37

0.108 ± 0.018

9

0.15 ± 0.047

9

0.096 ± 0.034

9

0.075 ± 0.023

10

0.109 ± 0.037

Testosterone

0.1

0.0005

32

0.032 ± 0.007

9

0.062 ± 0.02

8

0.028 ± 0.013

7

0.017 ± 0.008

8

0.023 ± 0.008

Deoxycorticosterone

0.1

0.0005

39

0.023 ± 0.003

12

0.03 ± 0.006

10

0.018 ± 0.003

10

0.019 ± 0.004

7

0.025 ± 0.009

Corticosterone sulphate

10

0.05

10

0.018 ± 0.01

3

0.022 ± 0.019

2

0.003 ± 0.002

1

0.001 ± 0.001

4

0.045 ± 0.032

11-Dehydrocorticosterone

0.1

0.0005

12

0.003 ± 0.001

4

0.005 ± 0.004

3

0.001 ± 0

2

0.002 ± 0.002

3

0.005 ± 0.003

Aldosterone

1

0.005

0

< LOQ

0

< LOQ

0

< LOQ

0

< LOQ

0

< LOQ

DHEA

10

0.05

0

< LOQ

0

< LOQ

0

< LOQ

0

< LOQ

0

< LOQ

Δ4-Androstenedione

10

0.05

0

< LOQ

0

< LOQ

0

< LOQ

0

< LOQ

0

< LOQ

Δ5-Androstenediol

1

0.005

0

< LOQ

0

< LOQ

0

< LOQ

0

< LOQ

0

< LOQ

17α-Hydroxypregnenolone

100

0.5

0

< LOQ

0

< LOQ

0

< LOQ

0

< LOQ

0

< LOQ

Cortisone sulphate

10

0.05

0

< LOQ

1

< LOQ

1

< LOQ

1

< LOQ

1

< LOQ

  1. aEquivalent to ng/mg of tissue LOQ
  2. bQuantifiable samples out of n samples as stated in brackets
  3. LOQ limit of quantitation, QS quorum sensing, SEM standard error of the mean
Back to article page

BMC Medicine

ISSN: 1741-7015

Contact us