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Table 2 Genetic risk burden of birthweight-reducing alleles by deleteriousness score

From: High burden of birthweight-lowering genetic variants in Africans and Asians

Populationa Relatively benign (n = 30 SNPs) Relatively deleterious (n = 29 SNPs)
Mean (s.d.) Mean difference compared to EUR (95% CI); P value Mean (s.d.) Mean difference compared to EUR (95% CI); P value
AFR 29.85 (2.846) 1.98 (0.38, 3.58); 0.016 34.68 (3.109) 1.18 (−0.51, 2.87); 0.167
AMR 28.28 (3.449) −0.41 (−1.35,2.17); 0.642 36.12 (3.768) 2.62 (0.76,4.48); 0.007
EAS 28.56 (3.127) 0.69 (−0.98,2.36); 0.412 35.66 (2.881) 2.16 (0.53, 3.79); 0.010
SAS 28.35 (3.332) 0.48 (−1.25,2.21); 0.579 34.10 (3.243) 0.60 (−1.12, 2.32); 0.488
EUR 27.87 (3.283) ref 33.50 (3.360) ref
  1. aFor each super-population, mean genetic risk burden of deleterious SNPs was significantly higher than that of benign SNPs. Mean differences: AFR (Africans) 4.83, AMR (admixed Americans) 7.84, EAS (East Asians) 7.1, SAS (South Asians) 5.75, EUR (Europeans) 5.63 (p < 0.001)
  2. AFR Africans, AMR admixed Americans, CI confidence interval, EAS East Asians, EUR Europeans, ref reference, SAS South Asians, s.d. standard deviation, SNP single-nucleotide polymorphism