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Table 3 Associations between genetically predicted serum magnesium levels and cardiometabolic risk factors

From: Serum magnesium levels and risk of coronary artery disease: Mendelian randomisation study

Outcome

Estimatea

P value

Continuous outcomes

Beta (95% CI)

Ā 

ā€ƒDiastolic blood pressure

0.46 (āˆ’0.34 to 1.26) mm Hg

0.26

ā€ƒSystolic blood pressure

1.31 (0.05 to 2.57) mm Hg

0.04

ā€ƒLow-density lipoprotein cholesterol

0.06 (āˆ’0.00 to 0.13) SD

0.07

ā€ƒHigh-density lipoprotein cholesterol

āˆ’0.03 (āˆ’0.09 to 0.03) SD

0.34

ā€ƒTriglycerides

0.06 (0.00 to 0.12) SD

0.04

ā€ƒFasting glucose

0.02 (āˆ’0.03 to 0.07) mmol/L

0.35

ā€ƒFasting insulin

0.02 (āˆ’0.03 to 0.07) log pmol/L

0.43

ā€ƒHOMA-IR

0.01 (āˆ’0.04 to 0.06)

0.67

ā€ƒBMI

āˆ’0.02 (āˆ’0.07 to 0.02) SD

0.34

ā€ƒWaist-to-hip ratio adjusted for BMI

0.02 (āˆ’0.03 to 0.07) SD

0.50

ā€ƒCigarettes per day

āˆ’0.59 (āˆ’1.66 to 0.49) cigarettes/day

0.29

Binary outcomes

OR (95% CI)

Ā 

ā€ƒEver smoker

1.00 (0.98 to 1.01)

0.62

ā€ƒFormer smoker

1.00 (0.98 to 1.02)

0.78

  1. BMI body mass index, CI confidence interval, HOMA-IR homeostatic model assessment of insulin resistance, OR odds ratio, SD standard deviation
  2. aEstimates correspond to a 0.1-mmol/L (about one SD) increase in genetically predicted serum magnesium levels
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BMC Medicine

ISSN: 1741-7015

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