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Table 3 Associations between genetically predicted serum magnesium levels and cardiometabolic risk factors

From: Serum magnesium levels and risk of coronary artery disease: Mendelian randomisation study

Outcome Estimatea P value
Continuous outcomes Beta (95% CI)  
 Diastolic blood pressure 0.46 (−0.34 to 1.26) mm Hg 0.26
 Systolic blood pressure 1.31 (0.05 to 2.57) mm Hg 0.04
 Low-density lipoprotein cholesterol 0.06 (−0.00 to 0.13) SD 0.07
 High-density lipoprotein cholesterol −0.03 (−0.09 to 0.03) SD 0.34
 Triglycerides 0.06 (0.00 to 0.12) SD 0.04
 Fasting glucose 0.02 (−0.03 to 0.07) mmol/L 0.35
 Fasting insulin 0.02 (−0.03 to 0.07) log pmol/L 0.43
 HOMA-IR 0.01 (−0.04 to 0.06) 0.67
 BMI −0.02 (−0.07 to 0.02) SD 0.34
 Waist-to-hip ratio adjusted for BMI 0.02 (−0.03 to 0.07) SD 0.50
 Cigarettes per day −0.59 (−1.66 to 0.49) cigarettes/day 0.29
Binary outcomes OR (95% CI)  
 Ever smoker 1.00 (0.98 to 1.01) 0.62
 Former smoker 1.00 (0.98 to 1.02) 0.78
  1. BMI body mass index, CI confidence interval, HOMA-IR homeostatic model assessment of insulin resistance, OR odds ratio, SD standard deviation
  2. aEstimates correspond to a 0.1-mmol/L (about one SD) increase in genetically predicted serum magnesium levels