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Table 3 Associations between genetically predicted serum magnesium levels and cardiometabolic risk factors

From: Serum magnesium levels and risk of coronary artery disease: Mendelian randomisation study

Outcome

Estimatea

P value

Continuous outcomes

Beta (95% CI)

 

 Diastolic blood pressure

0.46 (−0.34 to 1.26) mm Hg

0.26

 Systolic blood pressure

1.31 (0.05 to 2.57) mm Hg

0.04

 Low-density lipoprotein cholesterol

0.06 (−0.00 to 0.13) SD

0.07

 High-density lipoprotein cholesterol

−0.03 (−0.09 to 0.03) SD

0.34

 Triglycerides

0.06 (0.00 to 0.12) SD

0.04

 Fasting glucose

0.02 (−0.03 to 0.07) mmol/L

0.35

 Fasting insulin

0.02 (−0.03 to 0.07) log pmol/L

0.43

 HOMA-IR

0.01 (−0.04 to 0.06)

0.67

 BMI

−0.02 (−0.07 to 0.02) SD

0.34

 Waist-to-hip ratio adjusted for BMI

0.02 (−0.03 to 0.07) SD

0.50

 Cigarettes per day

−0.59 (−1.66 to 0.49) cigarettes/day

0.29

Binary outcomes

OR (95% CI)

 

 Ever smoker

1.00 (0.98 to 1.01)

0.62

 Former smoker

1.00 (0.98 to 1.02)

0.78

  1. BMI body mass index, CI confidence interval, HOMA-IR homeostatic model assessment of insulin resistance, OR odds ratio, SD standard deviation
  2. aEstimates correspond to a 0.1-mmol/L (about one SD) increase in genetically predicted serum magnesium levels