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Table 1 WHO Zika virus vaccine pipeline: in human trials (last updated September 2017 [29])

From: Zika vaccines and therapeutics: landscape analysis and challenges ahead

Platform Candidate vaccine Immunogen Adjuvant type Replicating virus Registry ID Trial status Sponsor name Sponsor type Phase Study start date Age Sample size Location
DNA GLS-5700 prM/E None No NCT02809443 Open, not recruiting GeneOne Life Science, Inc./Inovio Pharmaceuticals Industry Phase 1 1/7/16 Adult 40 United States of America, Canada
NCT02887482 Open, recruiting GeneOne Life Science, Inc./Inovio Pharmaceuticals Industry Phase 1 1/8/16 Adult 160 Puerto Rico
Peptide AGS-v Mosquito salivary proteins   No NCT03055000 Open, recruiting NIH Government Phase 1 9/2/17 Adult 60 United States of America
Recombinant viral vector MV-Zika prM/E None Yes NCT02996890 Open, recruiting Themis Bioscience Industry Phase 1 4/4/17 Adult 48 Austria
mRNA mRNA-1325 prM/E None No NCT03014089 Open, recruiting Moderna Therapeutics Industry Phase 2 1/12/16 Adult 90 United States of America
DNA VRC-ZKADNA085–00-VP or
VRC-ZKADNA090–00-VP
prM/E None No NCT02840487 Open, not recruiting NIAID Government Phase 1 11/7/16 Adult 120 United States of America
NCT02996461 Open, recruiting NIAID Government Phase 1 8/12/16 Adult 50 United States of America
NCT03110770 Open, recruiting NIAID Government Phase 2 29/3/17 Child, Adult 2500 United States of America, Puerto Rico
Inactivated whole target organism ZIKV PIV Full genome Aluminum No NCT02963909 Open, recruiting NIAID Government Phase 1 1/11/16 Adult 75 United States of America
NCT02952833 Open, recruiting NIAID Government Phase 1 14/10/16 Adult 90 United States of America
NCT02937233 Open, recruiting BIDMC Academic Phase 1 1/10/16 Adult 48 United States of America
NCT03008122 Open, recruiting NIAID Government Phase 1 24/2/17 Adult 90 Puerto Rico
Inactivated whole target organism BBV121 Full genome Aluminum No CTRI/2017/05/008539 Open, recruiting Bharat Biotech International Ltd., India Industry Phase 1 1/6/17 Adult 48 India
  1. BIDMC Beth Israel Deaconess Medical Center, NIAID National Institute of Allergy and Infectious Diseases, NIH National Institutes of Health, PIV purified, inactivated whole virus vaccines, ZIKV Zika virus
  2. #Reference: http://www.who.int/immunization/research/vaccine_pipeline_tracker_spreadsheet/en/