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Table 2 HRs (95% CIs) for incident chronic kidney disease according to HBsAg status among 469,459 participants

From: Chronic hepatitis B virus infection and risk of chronic kidney disease: a population-based prospective cohort study of 0.5 million Chinese adults

  HBsAg negative HBsAg positive p value
Whole cohort
 Number of cases 4381 174  
  Cases/PY (1000) 1.07 1.33  
   Age and sex adjusted 1.00 1.36 (1.17, 1.59) <0.001
   Multivariable adjusted* 1.00 1.37 (1.18, 1.60) <0.001
    + Presence of hepatitis or cirrhosis 1.00 1.33 (1.14, 1.55) <0.001
Men
 Number of cases 1671 91  
  Cases/PY (1000) 1.02 1.54  
   Age adjusted 1.00 1.81 (1.46, 2.24) <0.001
   Multivariable adjusted* 1.00 1.77 (1.43, 2.20) <0.001
    + Presence of hepatitis or cirrhosis 1.00 1.72 (1.38, 2.14) <0.001
Women
 Number of cases 2710 83  
  Cases/PY (1000) 1.11 1.15  
   Age adjusted 1.00 1.08 (0.86, 1.34) 0.517
   Multivariable adjusted* 1.00 1.10 (0.88, 1.36) 0.414
    + Presence of hepatitis or cirrhosis 1.00 1.06 (0.85, 1.33) 0.606
  1. CI confidence interval, HBsAg hepatitis virus B surface antigen, HR hazard ratio, PY person-year
  2. *Multivariable model was adjusted for: age (years); sex (men or women, for whole cohort); level of education (no formal school, primary school, middle school, high school, college, or university or higher); marital status (married, widowed, divorced or separated, or never married); alcohol consumption (less than weekly drinker, weekly drinker, daily drinker with an intake of <15, 15–29, 30–59, or ≥60 g/day); smoking status (nonsmoker, former smoker having quit smoking ≥5 or <5 years previously, or current daily smoker smoking <15, 15–24, or ≥25 cigarettes or equivalents per day); physical activity (MET-h/day); intake frequencies of red meat, fresh fruit, and fresh vegetables (daily, 4–6 days/week, 1–3 days/week, monthly, or rarely or never); body mass index (kg/m2); menopausal status (premenopausal, perimenopausal, or postmenopausal; for women only); prevalent diabetes; and prevalent hypertension at baseline (presence or absence)
  3. A composite variable of disease status (absence or presence), duration (< 15 or ≥ 15 years), and treatment status at baseline (no or yes)
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