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Fig. 2 | BMC Medicine

Fig. 2

From: Clinical utility of the S3-score for molecular prediction of outcome in non-metastatic and metastatic clear cell renal cell carcinoma

Fig. 2

Cancer-specific survival (CSS) of clear cell renal cell carcinoma (ccRCC) tumors of our validation cohort predicted by the simplified RT-PCR-based S315-score. Kaplan–Meier curves showing CSS of (a) the extended ccRCC cohort 2 (n = 108) and (b) the non-metastatic (n = 92) and metastatic subsets (n = 15) of this cohort. Groups are defined by the cut-off of the S315-score, as determined by conditional inference tree models. c S315-score significantly improves the established SSIGN prediction score. χ2 statistic values depict the improvement of the model likelihood when risk classification based on the S315-score (red) was added to the Cox model initially including only the SSIGN score (blue; left) or vice versa (right). χ2 test P values are shown in the bars. HR hazard ratio, CI confidence interval. Detailed information on statistical methods is provided in Additional file 1: Supplementary methods

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