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Table 1 Summary of malaria transmission model parameters

From: Modelling population-level impact to inform target product profiles for childhood malaria vaccines



Prevalence settings

5–50% in 5% increments. Four distinct transmission settings, with PfPR2–10 at start year set to 5%, 15%, 30% and 45%

Simulation size

30,000–65,000, depending on prevalence level


Perennial, with Fourier coefficients for the perennial setting as in Walker et al. [22]


40% coverage of artemisinin-based combination therapy (ACT) treatment with 95% efficacy

Vaccine coverage

Default value of 80% coverage for the first three vaccine doses, with fourth dose coverage at 80% of the coverage for the first three doses in line with Penny et al. [12]. Varied in the range 50–90% in 5% increments

Vaccine dose timing

First three RTS,S/AS01 vaccine doses administered at 5, 6.5 and 8 months of age. Fourth dose administered at 26 months (default) and varied in the range 16–30 months

  1. PfPR2–10 represents P. falciparum parasite prevalence in 2–10-year-old children