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Table 1 Criteria for classification of the credibility of the evidence (adapted from reference [31])

From: The association of depression and all-cause and cause-specific mortality: an umbrella review of systematic reviews and meta-analyses

Classification Criteria
Convincing evidence (Class I) More than 1000 death events
Significant summary associations (P < 10− 6) per random effects calculations
No evidence of small-study effects
No evidence of excess of significance
Prediction intervals not including the null
Not large heterogeneity (i.e., I2 < 50%)
Highly-suggestive evidence (Class II) Significant summary associations (P < 10− 6) per random effects calculation
More than 1000 death events
The largest study with 95% confidence intervals excluding the null
Suggestive evidence (Class III) More than 1000 death events
Significant summary associations (P < 10−3) per random effects calculations
Weak evidence All other associations with P < 0.05
Non-significant associations All associations with P > 0.05