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Table 2 Effect of physical activity on cognitive frailty using ordinal logistic regression models

From: Effect of 24-month physical activity on cognitive frailty and the role of inflammation: the LIFE randomized clinical trial

  Model 1 Model 2 Model 3
OR (95% CI) P value OR (95% CI) P value OR (95% CI) P value
Primary analysis
 Physical activity vs. health education 0.79 (0.64–0.98) 0.032 0.79 (0.64–0.98) 0.030 0.80 (0.65–0.97) 0.026
 Higher IL-6 vs. lower IL-6 1.11 (0.89–1.37) 0.357 1.09 (0.89–1.33) 0.400
Secondary analysis
 Physical activity vs. health education 0.77 (0.62–0.95) 0.015 0.77 (0.62–0.95) 0.014 0.77 (0.63–0.95) 0.012
 Higher IL-6 vs. lower IL-6 1.13 (0.91–1.40) 0.260 1.11 (0.91–1.36) 0.301
  1. The 1164 participants who had baseline data on cognitive frailty and IL-6 and follow-up data on cognitive frailty were included
  2. OR odds ratio, CI confidence interval, IL-6 interleukin-6
  3. Ordinal logistic regression was used as described in the Method section. For the primary analysis, ordinal variable 1 was created by assigning 0 for no cognitive frailty (i.e., non-frail without mild cognitive impairment [MCI]), 1 for pre-frail without MCI, 2 for frail without MCI, 3 for non-frail with MCI, 4 for pre-frail with MCI, and 5 for cognitive frailty (i.e., frail with MCI). For the secondary analysis, ordinal variable 2 was created by assigning 2 for non-frail with MCI and 3 for frail without MCI while the other values remained unchanged
  4. Model 1 adjusted for intervention, field center, sex, and baseline levels for cognitive frailty
  5. As the interaction between intervention groups and IL-6 subgroups was not statistically significant (P for interaction = 0.919 for primary analysis and 0.936 for secondary analysis), it was not included in Model 2
  6. Model 3 adjusted for the same covariates as in Model 2 but weighted for the inverse probability of remaining in the study