Table 3 Comparison of PC_1/2 between patients with WT and a pfk13 NS-mutation in Asia. Metric is the fold increase of PC_1/2 in mutants vs. wild type. Only mutations with n ≥ 5 are shown. With only two exceptions (K189T and K438N), all patients that carried parasites with the indicated pfk13 mutant codon showed a PC_1/2 significantly different from those that carried WT parasites

K189T

8

148

1.1

0.8–1.4

0.729

1.1

0.8–1.4

0.644

E252Q

114

589

1.5

1.4–1.6

< 0.001

1.5

1.4–1.6

< 0.001

K438N

10

386

0.9

0.7–1.1

0.251

0.9

0.7–1.1

0.237

P441L

53

565

2.1

1.9–2.3

< 0.001

2.2

2.0–2.4

< 0.001

F446I

79

303

1.6

1.4–1.7

< 0.001

1.5

1.4–1.7

< 0.001

G449A

6

41

1.9

1.4–2.6

< 0.001

1.9

1.3–2.7

< 0.001

N458Y

34

520

2.5

2.2–2.8

< 0.001

2.5

2.2–2.8

< 0.001

M476I

8

481

2

1.6–2.5

< 0.001

2.0

1.5–2.5

< 0.001

A481V

5

410

1.8

1.3–2.4

< 0.001

1.6

1.2–2.2

0.002

Y493H

33

313

2.6

2.2–3.0

< 0.001

2.7

2.3–3.1

< 0.001

R515K

5

352

1.9

1.4–2.6

< 0.001

2.0

1.5–2.7

< 0.001

P527H/L*

23

422

1.7

1.5-2.0

< 0.001

1.7

1.5–2.0

< 0.001

N537I

8

231

1.7

1.3–2.2

< 0.001

1.8

1.4–2.3

< 0.001

G538V

24

558

1.8

1.6–2.1

< 0.001

1.9

1.6–2.2

< 0.001

R539T

76

369

2.1

1.9–2.4

< 0.001

2.1

1.9–2.4

< 0.001

I543T

92

156

1.9

1.7–2.3

< 0.001

2.1

1.8–2.4

< 0.001

I543T**

27

140

2.8

2.3–3.4

< 0.001

2.8

2.3–3.5

< 0.001

P553L

16

529

2.2

1.8–2.6

< 0.001

2.2

1.8–2.8

< 0.001

R561H

36

310

2.2

1.9–2.5

< 0.001

2.2

1.9–2.6

< 0.001

V568G

5

127

2.7

1.8–4.1

< 0.001

2.7

1.8–4.1

< 0.001

P574L

48

739

1.8

1.6–2.0

< 0.001

2.0

1.7–2.2

< 0.001

P574L***

35

723

1.8

1.6–2.1

< 0.001

1.8

1.6–2.1

< 0.001

C580Y

450

997

2.2

2.1–2.4

< 0.001

2.3

2.1–2.4

< 0.001

P667T****

5

50

2.2

1.6–2.9

< 0.001

2.1

1.6–2.9

< 0.001

A675V

49

501

2.2

1.9–2.4

< 0.001

2.2

2.0–2.4

< 0.001