Fig. 2

Temporal evolution of HSV-1 seroprevalence in the US. a Estimated HSV-1 seroprevalence in people aged 10–49 years, compared to the National Health and Nutrition Examination Surveys (NHANES) data. b Estimated reduction in HSV-1 seroprevalence per age group between 1976–1980 and 2013–2014, compared to the measured reduction in NHANES data. c Estimated asymptomatic as well as ever-symptomatic and clinically diagnosed genital herpes prevalence in HSV-1-antibody-positive and HSV-2-antibody-negative 20–49 years old population—the latter compared to self-reported NHANES data. HSV-1 genital herpes is defined as any HSV-1 infection acquired genitally, regardless of presence or absence of disease or clinical manifestations