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Table 7 Odds ratios (95% confidence intervals) of groups of mental disorders (lifetime prevalence) regressed on immune-mediated classes, men and women

From: A step beyond the hygiene hypothesis—immune-mediated classes determined in a population-based study

  Neutral class Resilient class Atopic class Mixed class ACE class
Men
 Neurodevelopmental disorders 1 (ref.) 0.8 (0.5–1.2) 1.7 (1.0–3.0) 2.0 (1.3–3.2) 4.0 (2.4–6.5)
 Early anxiety disorders 1 (ref.) 0.8 (0.6–1.1) 1.1 (0.7–1.8) 2.0 (1.4–2.8) 2.7 (1.7–4.3)
 Late anxiety disorders 1 (ref.) 0.7 (0.5–1.0) 1.2 (0.7–2.1) 1.5 (1.0–2.4) 1.6 (0.9–2.9)
 Mood disorders 1 (ref.) 0.8 (0.7–1.0) 1.5 (1.0–2.2) 1.8 (1.3–2.5) 2.3 (1.5–3.4)
 Substance disorders 1 (ref.) 0.9 (0.7–1.2) 1.1 (0.7–1.6) 1.1 (0.8–1.6) 1.8 (1.1–2.8)
Women
 Neurodevelopmental disorders 1 (ref.) 0.6 (0.3–1.0) 0.9 (0.4–1.8) 1.6 (0.9–2.6) 3.8 (2.3–6.2)
 Early anxiety disorders 1 (ref.) 0.7 (0.5–0.9) 1.6 (1.2–2.2) 1.4 (1.1–1.9) 3.0 (2.1–4.2)
 Late anxiety disorders 1 (ref.) 0.8 (0.6–1.1) 1.2 (0.8–1.8) 1.6 (1.1–2.2) 2.7 (1.9–4.0)
 Mood disorders 1 (ref.) 0.9 (0.7–1.0) 1.1 (0.8–1.5) 1.4 (1.1–1.9) 2.2 (1.5–3.2)
 Substance disorders 1 (ref.) 0.6 (0.4–1.0) 1.8 (1.0–3.0) 1.6 (1.0–2.6) 2.7 (1.6–4.6)
  1. ACE adverse childhood experiences
  2. Groups of mental disorders: neurodevelopmental disorders—tics, attention-deficit hyperactivity disorder, conduct disorder, oppositional defiant disorder; early anxiety disorders—separation anxiety disorder, overanxious disorder, specific phobias (animals), social phobia; late anxiety disorders—generalized anxiety disorder, panic, agoraphobia, specific phobias (excl. animals); mood disorders—major depression disorder, dysthymia, bipolar disorders; substance disorders—alcohol, cannabis, other illicit drug abuse/dependence