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Table 1 Descriptive characteristics of coded NAFLD/NASH patients and matched unexposed cohorts

From: Risks and clinical predictors of cirrhosis and hepatocellular carcinoma diagnoses in adults with diagnosed NAFLD: real-world study of 18 million patients in four European cohorts

Baseline characteristics HSD - Italy IPCI - UK SIDIAP - Spain THIN - UK Total population
NAFLD/NASH Matched non-NAFLD/NASH NAFLD/NASH Matched non-NAFLD/NASH NAFLD/NASH Matched non-NAFLD/NASH NAFLD/NASH Matched non-NAFLD/NASH NAFLD/NASH Matched non-NAFLD/NASH
Follow-up years prior to index date: median (IQR) 7.5 (4.66–10.5) 7.7 (4.8–10.6) 2.2 (0.9–3.8) 2.2 (1–3.8) 5.2 (3.1–7.1) 5.2 (3.1–7.1) 13.4 (5.5–23.4) 13.9 (5.8–23.4) 5.4 (2.8–8.0) 5.5 (2.9–8.3)
Follow-up years post index date: median (IQR) 5.3 (2.7–8.1) 5.2 (2.7–7.9) 1.8 (0.8–3.2) 1.8 (0.8–3.3) 3.5 (1.7–5.6) 3.5 (1.7–5.7) 3.1 (1.3–5.9) 3.0 (1.3–5.7) 3.3 (1.5–5.8) 3.2 (1.5–5.7)
Age in years, mean (SD) 56.1 (14.4) 55.0 (13.7) 56.8 (13.9) 56.1 (13.5) 55.9 (13.4) 54.5 (13.1) 54.4 (13.4) 53.5 (13.5) 55.8 (13.6) 54.6 (13.3)
Gender, % of Males 57.3 54.7 49.2 48.5 52.6 48.8 51.5 51.0 52.7 50.1
Current smokers*, % 11.3 9.0 17.2 11.5 17.6 15.4 17.8 19.0 16.5 14.4
Body mass index in kg/m2, mean (SD) 29.8 (5.0) 27.5 (5.0) 30.8 (5.3) 28.3 (5.2) 31.4 (5.1) 28.7 (5.1) 32.5 (6.0) 28.5 (5.9) 31.3 (5.3) 28.5 (5.3)
Obesity (%) 21.5 9.0 23.6 9.0 39.5 18.1 49.6 18.2 36.0 15.4
History of type 2 diabetes (%) 17.6 11.0 20.4 9.2 19.9 10 21.5 7.1 19.8 9.6
History of hypertension (%) 47.2 36.6 36.0 26.2 42.6 29.3 41.2 25.9 42.2 29.6
Statin use (%) 22.0 15.8 33.2 22.0 6.9 6.8 32.6 18.5 16.9 12.1
Aspartate transaminase (IU/L), median (IQR) 24 (19–32) 20 (17–25) 29 (22–40) 23 (20–28) 29 (22–40) 22 (18–27) 31 (23–45) 22 (19–27) 28 (21–39) 21 (18–26)
Alanine transaminase (IU/L), median (IQR) 30 (20–48) 21 (16–29) 37 (25–55) 25 (18–33) 34 (22–53) 20 (15–28) 42 (26–65) 22 (17–31) 35 (23–54) 21 (16–29)
  1. *After imputation of missing as non-smokers. N number of individuals. For laboratory values, we exclude outlier values greater than mean + 3 × SD (mean and SD computed separately in NAFLD and non-NAFLD separately)