From: The XN-30 hematology analyzer for rapid sensitive detection of malaria: a diagnostic accuracy study
XN-30 and RDT (HRP-2 and pLDH) versus corrected microscopy results (n = 837) | ||||||||||
 | XN-30 | HRP-2 | Test ratio | p value | pLDH | Test ratio | p value | |||
Pos | Neg | Pos | Neg | 95% CI | Â | Pos | Neg | 95% CI | Â | |
Microscopy positive | 234 | 3 | 231 | 6 | Â | Â | 208 | 29 | Â | Â |
Microscopy negative | 21 | 579 | 136 | 464 | Â | Â | 9 | 591 | Â | Â |
Sensitivity | 98.7% |  | 97.5% |  | 0.99 (0.97–1.01) | p = .45 | 87.8% |  | 0.89 (0.85–0.93) | p < .0001 |
Specificity | 96.5% |  | 77.3% |  | 6.47 (4.31–9.73) | p < .0001 | 98.5% |  | 0.43 (0.23–0.81) | p = .012 |
PPV | 91.8% | Â | 62.9% | Â | Â | Â | 95.9% | Â | Â | Â |
NPV | 99.5% | Â | 98.7% | Â | Â | Â | 95.3% | Â | Â | Â |
XN-30 and RDT (HRP-2 and pLDH) versus qPCR results (n = 837) | ||||||||||
 | XN-30 | HRP-2 | Test ratio | p value | pLDH | Test ratio | p value | |||
Pos | Neg | Pos | Neg | 95% CI | Â | Pos | Neg | 95% CI | Â | |
qPCR > 0.05 p/μL | 253 | 104 | 308 | 49 |  |  | 215 | 142 |  |  |
qPCR < 0.05 p/μL | 2 | 478 | 59 | 421 |  |  | 2 | 478 |  |  |
Sensitivity | 70.9% |  | 86.3% |  | 1.22 (1.15–1.29) | < 0.0001 | 60.2% |  | 0.85 (0.80–0.89) | < .0001 |
Specificity | 99.6% |  | 87.7% |  | 0.04 (0.01–0.14) | < 0.0001 | 99.6% |  | 1.0 (0.07–13.8) | 1.0 |
PPV | 99.2% | Â | 83.9% | Â | Â | Â | 99.1% | Â | Â | Â |
NPV | 82.1% | Â | 89.6% | Â | Â | Â | 77.1% | Â | Â | Â |