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Table 2 Type of study designs identified for each clinical domain

From: A rapid research needs appraisal methodology to identify evidence gaps to inform clinical research priorities in response to outbreaks—results from the Lassa fever pilot

Domain Study design
Non-randomized controlled studies Cohort studies Case-control studies Cross-sectional studies Case series# Case report#
Clinical phenotype and natural history of disease 1 article [18] 18 articles* [19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38] 3 articles [39,40,41] 7 articles [42,43,44,45,46,47,48] 21 articles [49,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64,65,66,67,68,69] 27 articles [70,71,72,73,74,75,76,77,78,79,80,81,82,83,84,85,86,87,88,89,90,91,92,93,94,95,96]
Transmission and prevention   10 articles** [22, 29, 38, 97,98,99,100,101,102,103]   3 articles [42, 43, 104] 3 articles [61, 62, 105] 7 articles [73, 74, 83, 84, 91, 92, 106]
Diagnostics   5 articles** [19, 37, 107,108,109] 1 article [110] 2 articles [46, 111, 112] 1 article [69] 4 articles [55, 74, 82, 113]
Immune response   4 articles** [31, 32, 107, 114]   2 articles [44, 46] 6 articles [52, 65, 115,116,117,118] 9 articles [55, 70, 72, 73, 76, 86, 91,92,93]
Drug therapy and supportive care 1 article [119] 7 articles** [19, 21, 24, 38, 120,121,122]   3 articles [42, 123, 124] 8 articles [49, 51,52,53, 56, 64, 66, 125] 17 articles [55, 71, 73,74,75,76,77,78, 80, 81, 83, 85, 86, 89, 95, 96, 126]
Risk factors for more severe disease   3 articles [37, 38, 114]   1 article [44]   
  1. *4 not extracted
  2. **1 not data extracted
  3. #Not extracted since higher level of evidence available for the domains covered in each article