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Table 2 Clinical characteristics associated with the diagnosis of monogenic diabetes: multivariable analysis

From: Next-generation sequencing identifies monogenic diabetes in 16% of patients with late adolescence/adult-onset diabetes selected on a clinical basis: a cross-sectional analysis

  Monogenic vs. non-monogenica Monogenic excluding GCK vs. non-monogenic GCK only vs. non-monogenic
N: monogenic vs. non-monogenic 194 vs. 926 113 vs.926 81 vs. 926
Variable P OR [95% CI] P OR [95% CI] P OR [95% CI]
 Sex: female vs. male 0.2866 1.22 [0.84–1.77] 0.2139 1.32 [0.85–2.05] 0.6597 1.13 [0.65–1.98]
 EuroCaucasian origin: yes vs. no < 10−4 3.83 [2.48–5.95] < 10−4 2.70 [1.66–4.41] < 10−4 9.17 [3.57–23.26]
N affected generations ≥ 3: yes vs. no 0.0136 1.57 [1.10–2.25] 0.0036 1.91 [1.24–2.96] 0.798 1.07 [0.63–1.81]
 Age at diabetes < 10−4 1.09 [1.07–1.11] < 10−4 1.09 [1.06–1.11] < 10−4 1.10 [1.06–1.13]
 BMI at diabetes < 10−4 1.13 [1.08–1.17] 0.0001 1.09 [1.04–1.14] < 10−4 1.19 [1.11–1.27]
 Symptoms of diabetes: yes vs. no < 10−4 0.30 [0.19–0.47] 0.0036 0.48 [0.29–0.78] < 10−4 0.06 [0.02–0.19]
AUC of the ROC analysis 0.82 0.79 0.89
  1. aNon-monogenic, no genetic etiology detected by targeted NGS on 7 genes
  2. BMI body mass index