Table 1 Demographics, baseline characteristics and baseline haemoglobin measurements
| Â | Chloroquine alone | Chloroquine plus primaquine | Overall | ||||||
|---|---|---|---|---|---|---|---|---|---|
Number (%)* | Mean Hb (SD) | Range | Number (%)* | Mean Hb (SD) | Range | Number (%)* | Mean Hb (SD) | Range | |
Overall | 1975 (100) | 12.2 (2.1) | 6.0 to 18.7 | 1446 (100) | 12.7 (2.1) | 4.0 to 19.0 | 3421 (100) | 12.4 (2.1) | 4.0 to 19.0 |
 Parasitaemia, parasites per uL; median (IQR) | 3400 (1261, 8290) |  |  | 2700 (912, 7040) |  |  | 3104 (1137, 8000) |  |  |
Gender | |||||||||
 Female | 772 (39.1) | 11.8 (1.9) | 6.0 to 17.4 | 438 (30.3) | 11.7 (1.8) | 4.0 to 17.4 | 1210 (35.4) | 11.7 (1.9) | 4.0 to 17.4 |
 Male | 1203 (60.9) | 12.5 (2.1) | 6.6 to 18.7 | 1008 (69.7) | 13.1 (2.1) | 4.9 to 19.0 | 2211 (64.6) | 12.8 (2.1) | 4.9 to 19.0 |
Age category, years | |||||||||
 < 5 | 225 (11.4) | 10.7 (2.0) | 6.0 to 16.6 | 72 (5.0) | 10.3 (1.8) | 4.9 to 14.1 | 297 (8.7) | 10.6 (2.0) | 4.9 to 16.6 |
 5 to < 15 | 691 (35.0) | 11.6 (1.8) | 6.6 to 17.4 | 326 (22.5) | 11.5 (1.6) | 5.5 to 16.3 | 1017 (29.7) | 11.6 (1.8) | 5.5 to 17.4 |
 ≥ 15 | 1059 (53.6) | 13.0 (1.9) | 6.2 to 18.7 | 1048 (72.5) | 13.2 (2.0) | 4.0 to 19.0 | 2107 (61.6) | 13.1 (2.0) | 4.0 to 19.0 |
Weight category, kg | |||||||||
 5 to < 15 | 195 (9.9) | 10.4 (1.9) | 6.0 to 16.3 | 83 (5.7) | 10.3 (1.6) | 5.2 to 13.4 | 278 (8.1) | 10.4 (1.8) | 5.2 to 16.3 |
 15 to < 25 | 440 (22.3) | 11.5 (1.9) | 6.9 to 16.6 | 172 (11.9) | 11.1 (1.6) | 4.9 to 15.9 | 612 (17.9) | 11.4 (1.8) | 4.9 to 16.6 |
 25 to < 35 | 182 (9.2) | 11.7 (1.6) | 6.6 to 16.2 | 94 (6.5) | 11.7 (1.6) | 7.5 to 15.1 | 276 (8.1) | 11.7 (1.6) | 6.6 to 16.2 |
 35 to < 45 | 196 (9.9) | 12.1 (1.9) | 6.5 to 17.4 | 153 (10.6) | 12.1 (1.9) | 5.8 to 17.1 | 349 (10.2) | 12.1 (1.9) | 5.8 to 17.4 |
 45 to < 55 | 404 (20.5) | 12.9 (1.9) | 6.2 to 18.7 | 338 (23.4) | 12.9 (1.9) | 5.4 to 18.1 | 742 (21.7) | 12.9 (1.9) | 5.4 to 18.7 |
 55 to < 80 | 484 (24.5) | 13.1 (1.9) | 7.0 to 18.1 | 508 (35.1) | 13.6 (1.9) | 4.0 to 19.0 | 992 (29.0) | 13.3 (1.9) | 4.0 to 19.0 |
 ≥ 80 | 74 (3.7) | 13.8 (1.3) | 9.9 to 16.5 | 98 (6.8) | 14.0 (1.7) | 8.2 to 17.9 | 172 (5.0) | 13.9 (1.5) | 8.2 to 17.9 |
G6PD status | |||||||||
 Normal | 856 (43.3) | 12.4 (1.9) | 6.5 to 18.1 | 836 (57.8) | 12.8 (2.0) | 5.4 to 19.0 | 1692 (49.5) | 12.6 (2.0) | 5.4 to 19.0 |
 Borderline | 3 (0.2) | 13.9 (1.1) | 13.1 to 15.2 | 0 (0) | – | – | 3 (0.1) | 13.9 (1.1) | 13.1 to 15.2 |
 Deficient | 24 (1.2) | 12.4 (1.8) | 8.6 to 15.7 | 1 (0.1) | 14.0 (−) | 14.0 to 14.0 | 25 (0.7) | 12.4 (1.8) | 8.6 to 15.7 |
 Not known | 1092 (55.3) | 12.1 (2.2) | 6.0 to 18.7 | 609 (42.1) | 12.5 (2.2) | 4.0 to 18.9 | 1701 (49.7) | 12.2 (2.2) | 4.0 to 18.9 |
Relapse periodicity | |||||||||
 Long | 1360 (68.9) | 12.3 (2.1) | 6.0 to 18.1 | 627 (43.4) | 13.4 (1.9) | 4.0 to 18.9 | 1987 (58.1) | 12.6 (2.1) | 4.0 to 18.9 |
 Short | 615 (31.1) | 12.1 (2.0) | 6.2 to 18.7 | 819 (56.6) | 12.2 (2.1) | 4.9 to 19.0 | 1434 (41.9) | 12.2 (2.0) | 4.9 to 19.0 |
Geographical region | |||||||||
 Asia-Pacific | 1114 (56.4) | 11.9 (1.9) | 6.2 to 18.7 | 1133 (78.4) | 12.5 (2.1) | 4.9 to 19.0 | 2247 (65.7) | 12.2 (2.0) | 4.9 to 19.0 |
 The Americas | 285 (14.4) | 12.5 (2.0) | 7.0 to 17.4 | 313 (21.6) | 13.5 (1.8) | 4.0 to 18.9 | 598 (17.5) | 13.0 (2.0) | 4.0 to 18.9 |
 Africa | 576 (29.2) | 12.7 (2.2) | 6.0 to 18.1 | 0 (0) | – | – | 576 (16.8) | 12.7 (2.2) | 6.0 to 18.1 |