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Fig. 4 | BMC Medicine

Fig. 4

From: Vitamin D and cause-specific vascular disease and mortality: a Mendelian randomisation study involving 99,012 Chinese and 106,911 European adults

Fig. 4

Instrumental variable estimates for lipids. Linear regression was also used to assess the associations of a two-SNP score with lipids. We used a two-SNP score as instrument to estimate the influence of a 25 nmol/L increase in 25(OH)D concentrations on lipids. We calculated instrumental variable estimates of genetically determined hazard ratios by using the Wald-type estimator, which involves taking the ratio of the gene-outcome coefficient to the gene-exposure coefficient. Two-SNP score was calculated based on DHCR7 + CYP2R1: rs12785878 + rs10741657 in CKB and DHCR7 + CYP2R1: rs7944926 + rs10741657 in CGPS. The r2 between rs12785878 and rs7944926 is 0.87. All values are adjusted for age, sex, and season and stratified by region

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BMC Medicine

ISSN: 1741-7015

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