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Table 3 Associations between C2 and PC ae C 36:3 and risk of breast cancer

From: Prospective analysis of circulating metabolites and breast cancer in EPIC

 Cases/controlsModel 1cModel 2—adjusted for WCModel 3—adjusted for weightModel 4—adjusted for HC
OR (95% CI)OR (95% CI)OR (95% CI)OR (95% CI)
C2
 Per SD increment1624/16241.15 (1.06–1.24)1.14 (1.06–1.23)1.15 (1.06–1.24)1.14 (1.06–1.24)
C2 (quintiles)a
 1287/3221.00 (ref.)1.00 (ref.)1.00 (ref.)1.00 (ref.)
 2291/3261.02 (0.81–1.28)1.00 (0.79–1.26)1.00 (0.80–1.27)1.00 (0.80–1.26)
 3322/3241.15 (0.91–1.44)1.12 (0.89–1.41)1.13 (0.90–1.42)1.13 (0.89–1.42)
 4311/3261.12 (0.89–1.41)1.09 (0.87–1.37)1.09 (0.87–1.37)1.10 (0.87–1.38)
 5413/3261.54 (1.21–1.95)1.51 (1.19–1.91)1.53 (1.20–1.93)1.52 (1.20–1.93)
P trendb 0.00020.00050.00040.0004
PC ae C36:3
 Per SD increment1624/16240.88 (0.82–0.95)0.90 (0.83–0.97)0.90 (0.83–0.96)0.89 (0.83–0.96)
PC ae C36:3 (quintiles)a
 1367/3251.00 (ref.)1.00 (ref.)1.00 (ref.)1.00 (ref.)
 2363/3230.99 (0.80–1.23)1.01 (0.82–1.25)1.02 (0.82–1.26)1.02 (0.82–1.26)
 3357/3260.96 (0.77–1.19)0.98 (0.79–1.22)0.98 (0.79–1.22)0.97 (0.78–1.21)
 4264/3260.70 (0.56–0.88)0.73 (0.58–0.91)0.73 (0.58–0.91)0.72 (0.58–0.91)
 5273/3240.73 (0.58–0.91)0.77 (0.61–0.96)0.76 (0.61–0.96)0.75 (0.60–0.95)
P trendb 0.00030.00200.00160.0010
  1. CI confidence interval, HC hip circumference, OR odds ratio, SD standard deviation, WC waist circumference
  2. aQuintile cut-points were determined on control participants
  3. For log-transformed C2, cut-points were as follows, in log(μmol/L): < 1.18/1.18–1.37/1.37–1.55/1.55–1.77/≥ 1.77. For log-transformed PC ae C36:3, cut-points were as follows, in log(μmol/L): < 1.81/1.81–1.94/1.94–2.04/2.04–2.16/≥ 2.16
  4. bFor test of linear trends across quintiles, participants were assigned the median value in each category and the corresponding variable was modeled as a continuous term
  5. cConditional logistic regression conditioned on matching factors