Category | Criteria | Number of possibilities |
---|---|---|
Medical condition | Inclusion of all studies (AUDs and/or AD) Exclusion of studies including patients with AUDs | 2 |
Abstinence† | Inclusion of all studies (abstinent or non-abstinent patients) Exclusion of studies requiring a minimum period of abstinence of 5 days or more before the beginning of the study | 2 |
Gender | Inclusion of all studies (mixed gender, males only or females only) Exclusion of studies with males or females only | 2 |
Somatic comorbidity | Inclusion of all studies (patients with or without systematic somatic comorbidities) Exclusion of studies on patients with systematic somatic comorbidities (e.g. studies on patients with HIV) | 2 |
Psychiatric comorbidity | Inclusion of all studies (patients with or without systematic psychiatric comorbidities) Exclusion of studies on patients with systematic psychiatric comorbidities (e.g. studies on depressed patients) | 2 |
Psychological support | Inclusion of all studies (with or without psychological intervention) Exclusion of studies with no psychological intervention | 2 |
Treatment and dose | Only approved dose and route of administration Approved dose and route of administration OR closest dose to the approved dose Maximum dose tested | 3 |
Treatment duration | Inclusion of all studies, regardless of treatment duration Exclusion of studies with a treatment duration of less than 12 weeks | 2 |
Outcome‡ | Quantity of alcohol consumed* Frequency of drinking** Abstinence*** | 3 |
Publication | Published and unpublished studies (e.g. study reports, ClinicalTrials.gov) Exclusion of unpublished studies | 2 |
Risk of bias | Inclusion of all studies, regardless of the risk of selective outcome reporting Exclusion of studies with a high risk of selective outcome reporting | 2 |
Analysis | Fixed effect model Random effect model | 2 |
Total of possible combinations | 9216 |