Fig. 1From: Does low-density lipoprotein cholesterol induce inflammation? If so, does it matter? Current insights and future perspectives for novel therapiesInflammasomes are key signaling platforms that detect atherogenic microorganisms and sterile stressors, and that activate the highly pro-inflammatory cytokines interleukin (IL)-1β and IL-18. Inhibition of IL-1β/IL-6 signaling, which is initiated at the level of the nucleotide-binding leucine-rich repeat-containing pyrine receptor 3 (NLRP3) inflammasome, may therefore effectively reduce atherosclerotic CV outcomes. CRP C-reactive protein, LDL low-density lipoprotein, PAI-1 plasminogen activator inhibitor-1Back to article page