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Table 1 The FOCUS evidence base and its relevance in the assessment of interventions targeting frailty based on the Evidence-to-Decision (EtD) criteria

From: Interventions to prevent, delay or reverse frailty in older people: a journey towards clinical guidelines

FOCUS project deliverablesa Evidence type EtD criteria for which the evidence was considered relevant
Systematic review of the effectiveness of interventions on frailty (D4.1.2) [11] Quantitative: A systematic review of randomised studies on interventions on frailty in older people, including health economy studies Benefits, harms, resource use, cost-effectiveness, equity
Review of qualitative studies on frailty interventions with stakeholders (D4.1.3) [12] Qualitative: A meta-synthesis of qualitative studies on stakeholders’ views and experiences of care and interventions in the context of frailty Outcome importance, value, equity, acceptability, feasibility
Thematic summary of focus groups with stakeholders in three different EU states (D4.1.4) [13] Qualitative: An inductive thematic analysis of semi-structured focus groups and individual interviews in three European countries (Italy, Poland, UK) with five groups of stakeholders, including frail and non-frail older adults, family caregivers, and health and social care professionals Outcome importance, value, equity, acceptability, feasibility
Thematic summary of joint focus groups with EU policy-makers (D4.1.5) [14] Qualitative: An inductive thematic analysis of semi-structured interviews with seven healthcare policy-makers across Europe Outcome importance, value, equity, acceptability, feasibility
Structured survey of partners within the EIP-AHA (D4.1.7) [15] Mixed: A structured survey seeking the opinions of EIP-AHA partners Outcome importance, value, equity, acceptability, feasibility
Realist review (D4.1.8) [16] Mixed: A realist review combining findings from the different components to examine what works, for whom and in what circumstances Outcome importance, value, equity, acceptability, feasibility
Comprehensive report of the results of the comparative analyses and modelling (FOCUS internal deliverable D5.2.1–5) Quantitative: Comparative analyses of EIP-AHA commitments upon structure, process and outcome indicators; modelling analyses of significant predictors of outcome, health and social care needs and use in the frame of frailty, with projected impact of changes in frailty as a result of interventions Resource use and feasibility (additional considerations)
  1. EIP-AHA European Innovation Partnership on Active and Healthy Aging, EU European Union
  2. aDeliverables are enumerated and titled based on FOCUS Grant Agreement