Fig. 1

Mean concentration of insulin and glucose at 0, 30, 60, and 120 min during an oral glucose tolerance test. Insulin and glucose trajectories for insulin-sensitive subgroup of normal glucose tolerance (IS-NGT, dashed blue, n = 708), insulin-resistant subgroup of normal glucose tolerance (IR-NGT, solid blue, n = 713), impaired fasting glucose (IFG, green, n = 1380), impaired glucose tolerance (purple, n = 412), and newly-diagnosed type 2 diabetes (red, NDM, n = 106) are shown. IS-NGT was defined as the bottom quartile of fasting insulin within NGT, and IR-NGT was defined as the top quartile. The dots denote mean absolute concentrations. Interquartile ranges are listed in Table 1